L773:0079 6123 OR L773:1875 7855 OR L773:9780444642608
Search: L773:0079 6123 OR L773:1875 7855 OR L773:9780444642608 > Nanoparticles aggra...
- 11 of 118
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03080naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-17230 | |
| 003 | SwePub | |
| 008 | 080618s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172302 URI |
| 024 | 7 | a https://doi.org/10.1016/S0079-6123(06)62013-X2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Sharma, Hari Shankeru Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut0 (Swepub:uu)hssharma |
| 245 | 1 0 | a Nanoparticles aggravate heat stress induced cognitive deficits, blood-brain barrier disruption, edema formation and brain pathology |
| 264 | 1 | c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Our knowledge regarding the influence of nanoparticles on brain function in vivo during normal or hyperthermic conditions is still lacking. Few reports indicate that when nanoparticles enter into the central nervous system (CNS) they may induce neurotoxicity. On the other hand, nanoparticle-induced drug delivery to the brain enhances neurorepair processes. Thus, it is likely that the inclusion of nanoparticles in body fluid compartments alters the normal brain function and/or its response to additional stress, e.g., hyperthermia. New data from our laboratory show that nanoparticles derived from metals (e.g., Cu, Ag or Al, approximately 50-60nm) are capable of inducing brain dysfunction in normal animals and aggravating the brain pathology caused by whole-body hyperthermia (WBH). Thus, normal animals treated with nanoparticles (for 1 week) exhibited mild cognitive impairment and cellular alterations in the brain. Subjection of these nanoparticle-treated rats to WBH resulted in profound cognitive and motor deficits, exacerbation of blood-brain barrier (BBB) disruption, edema formation and brain pathology compared with naive animals. These novel observations suggest that nanoparticles enhance brain pathology and cognitive dysfunction in hyperthermia. The possible mechanisms of nanoparticle-induced exacerbation of brain damage in WBH and its functional significance in relation to our current knowledge are discussed in this review. | |
| 653 | a aluminum | |
| 653 | a blood-brain barrier | |
| 653 | a body temperature | |
| 653 | a brain edema | |
| 653 | a cerebral blood flow | |
| 653 | a cognitive function | |
| 653 | a copper | |
| 653 | a heat stress | |
| 653 | a hyperthermia | |
| 653 | a nanoparticles | |
| 653 | a neurotoxicity | |
| 653 | a silver | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Sharma, Arunau Uppsala universitet,Institutionen för kirurgiska vetenskaper4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org |
| 773 | 0 | t Progress in Brain Researchg 162, s. 245-273q 162<245-273x 0079-6123x 1875-7855 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17230 |
| 856 | 4 8 | u https://doi.org/10.1016/S0079-6123(06)62013-X |
Find in a library
- Progress in Brain Research (Search for host publication in LIBRIS)
To the university's database
- 11 of 118
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Sharma, Hari Sha ...
- Sharma, Aruna
- Articles in the publication
- Progress in Brai ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
