Can MRI predict olfactory loss and improvement in posttraumatic olfactory dysfunction?

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Fältnamn	Indikatorer	Metadata
000		04023naa a2200505 4500
001		oai:DiVA.org:su-228702
003		SwePub
008		240429s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:237955246
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2287022 URI
024	7	a https://doi.org/10.4193/Rhin23.2462 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2379552462 URI
040		a (SwePub)sud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hsieh, Julien W.4 aut
245	1 0	a Can MRI predict olfactory loss and improvement in posttraumatic olfactory dysfunction?
264	1	c 2024
338		a print2 rdacarrier
520		a BACKGROUND: Although most patients with post-traumatic olfactory dysfunction (PTOD) undergo MRI, there is no consensus about its diagnostic or prognostic value.The aims were: 1) to classify the extent of post-traumatic neurodegeneration; 2) todetermine its relationship with chemosensory dysfunction (smell, taste, trigeminal); and 3) to establish whether MRI can predict olfactory improvement. METHODOLOGY: We conducted a retrospective cohort study based on a series of 56 patients with PTOD. All patients underwent validated psychophysical tests of their smell, taste, and trigeminal functions, otorhinolaryngologic evaluation, and MRI. An experiencedradiologist blinded to patient data evaluated 40 chemosensory-relevant brain regions according to a four-point scale (0=no lesion to 3=large lesion). Follow up data after 4 years (on average) were available in 46 patients. RESULTS:The cluster analysis showed 4 brain lesion patterns that differed in lesion localization and severity. They are associatedwith diagnostic categories: anosmia, hyposmia and normosmia. Two clusters were highly specific for anosmia (100% specificity)and could accurately predict this condition (100% positive predictive value). No clusters were associated with trigeminal or tastedysfunction. Regarding improvement, 72.7% of patients in the cluster with mild lesions experienced subjective and measurable olfactory improvement whereas this was only the case in 21.7-37.5% of patients with larger lesions. The odds of subjective smellimprovement were 5.9 times higher in patients within the milder cluster compared to larger ones. CONCLUSIONS: The analysis of brain lesions in PTOD allows corroboration of smell test results and prediction of subjective and measurable improvement.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oto-rhino-laryngologi0 (SwePub)302182 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Otorhinolaryngology0 (SwePub)302182 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653		a olfaction
653		a taste
653		a trigeminal
653		a head trauma
653		a MRI
700	1	a Lenoir, Vincent4 aut
700	1	a Sipione, Rebecca4 aut
700	1	a Hugentobler, Marianne4 aut
700	1	a Daskalou, Dimitrios4 aut
700	1	a Lundström, Johan N.,d 1973-u Stockholms universitet,SUBIC – Centrum för hjärnavbildning vid Stockholms universitet,Karolinska Institutet, Sweden; Monell Chemical Senses Center, United States4 aut0 (Swepub:su)nilu6044
700	1	a Senn, Pascal4 aut
700	1	a Rimmer, Joanne4 aut
700	1	a Becker, Minerva4 aut
700	1	a Landis, Basile N.4 aut
710	2	a Stockholms universitetb SUBIC – Centrum för hjärnavbildning vid Stockholms universitet4 org
773	0	t Rhinologyg 62:2, s. 172-182q 62:2<172-182x 0300-0729x 1996-8604
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-228702
856	4 8	u https://doi.org/10.4193/Rhin23.246
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:237955246

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Av författaren/redakt...: Hsieh, Julien W.; Lenoir, Vincent; Sipione, Rebecca; Hugentobler, Mar ...; Daskalou, Dimitr ...; Lundström, Johan ...; visa fler...; Senn, Pascal; Rimmer, Joanne; Becker, Minerva; Landis, Basile N ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oto rhino laryng ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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Av lärosätet: Stockholms universitet; Karolinska Institutet

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