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Low-Dose Oral Ketam...
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Rayala, SpandanaMNJ Institute of Oncology and Regional Cancer Center
(författare)
Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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Mary Ann Liebert Inc,2019
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:0fb14a9f-7d00-4204-ae59-44120da41ce0
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https://lup.lub.lu.se/record/0fb14a9f-7d00-4204-ae59-44120da41ce0URI
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https://doi.org/10.1089/jpm.2018.0667DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Aim: The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting. Methods: Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a two-armed blinded placebo-controlled trial where 0.8 mg/kg (bodyweight) of ketamine mixed in juice was given 30 minutes before the procedure to Group K (ketamine) compared with placebo, only juice, to Group P (placebo). In addition, topical analgesia (EMLA®) was given according to established standard of care. Patients and caregivers assessed the pain using the Wong-Baker Faces Pain Rating Scale. Results: A total number of 52 patients, equally distributed between Group K and Group P, were included in the study. The placebo-controlled group had significantly higher self-reported pain score than the group receiving ketamine (p = 0.046), as well as in caregiver-assessed pain (p = 0.033). Only three incidents of mild adverse effects were reported. Conclusion: Low-dose oral ketamine can be safely administered for procedural analgesia in pediatric cancer patients undergoing LP in a resource-limited hospital setting and have significant pain-reducing effect compared with placebo.
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Bäckdahl, TimLund University
(författare)
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Reddy, NareshMNJ Institute of Oncology and Regional Cancer Center
(författare)
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Jacob, JeanTwo Worlds Cancer Collaboration,MNJ Institute of Oncology and Regional Cancer Center
(författare)
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Gebre-Medhin, ErikLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-ege
(författare)
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Karonen, EmilLund University
(författare)
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Palat, GayatriMNJ Institute of Oncology and Regional Cancer Center
(författare)
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Sinha, SudhaMNJ Institute of Oncology and Regional Cancer Center
(författare)
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Schyman, TommySkåne University Hospital
(författare)
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Wiebe, ThomasLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-twi
(författare)
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Brun, EvaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Head and Neck Cancer Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)onk-ebr
(författare)
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Segerlantz, MikaelLund University,Lunds universitet,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Palliativ vård,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,The Institute for Palliative Care,Lund University Research Groups,Palliative care,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne, Primary health care(Swepub:lu)mi8756se
(författare)
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MNJ Institute of Oncology and Regional Cancer CenterLund University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Palliative Medicine: Mary Ann Liebert Inc22:11, s. 1357-13631096-62181557-7740
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Rayala, Spandana
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Bäckdahl, Tim
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Reddy, Naresh
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Jacob, Jean
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Gebre-Medhin, Er ...
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Karonen, Emil
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visa fler...
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Palat, Gayatri
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Sinha, Sudha
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Schyman, Tommy
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Wiebe, Thomas
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Brun, Eva
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Segerlantz, Mika ...
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Lunds universitet