Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-beta Load

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Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-beta Load

Chatterjee, P. (author)

Mohammadi, M. (author)

Goozee, K. (author)

Shah, T. M. (author)

Sohrabi, H. R. (author)

Dias, C. B. (author)

Shen, K. K. (author)

Asih, P. R. (author)

Dave, P. (author)

Pedrini, S. (author)

Ashton, Nicholas J. (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Hye, A. (author)

Taddei, K. (author)

Lovejoy, D. B. (author)

Zetterberg, Henrik, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Blennow, Kaj, 1958 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Martins, R. N. (author)

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IOS Press, 2020
2020
English.
In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 76:1, s. 291-301

Related links:: https://content.iosp...; show more...; https://gup.ub.gu.se...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background/Objective: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation. Given that iron dyshomeostasis has been observed in Alzheimer's disease (AD) together with elevated serum hepcidin levels, the current study examined whether elevated serum hepcidin levels are an early event in AD pathogenesis by measuring the hormone in cognitively normal older adults at risk of AD, based on high neocortical amyloid-beta load (NAL). Methods: Serum hepcidin levels in cognitively normal participants (n = 100) aged between 65-90 years were measured using ELISA. To evaluate NAL, all participants underwent 18F-florbetaben positron emission tomography. A standard uptake value ratio (SUVR)<1.35 was classified as low NAL (n = 65) and >= 1.35 (n = 35) was classified as high NAL. Results: Serum hepcidin was significantly higher in participants with high NAL compared to those with low NAL before and after adjusting for covariates: age, gender, and APOE epsilon 4 carriage (p < 0.05). A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished high from low NAL (area under the curve, AUC = 0.766), but was outperformed when serum hepcidin was added to the base model (AUC = 0.794) and further improved with plasma A beta(42/40) ratio (AUC = 0.829). Conclusion: The present findings indicate that serum hepcidin is increased in individuals at risk for AD and contribute to the body of evidence supporting iron dyshomeostasis as an early event of AD. Further, hepcidin may add value to a panel of markers that contribute toward identifying individuals at risk of AD; however, further validation studies are required.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Alzheimer's disease
amyloid deposits
hepcidin
iron dyshomeostasis
positron emission tomography
alzheimers-disease
iron dyshomeostasis
ferroportin
macrophages
biomarkers
deposition
dementia
Neurosciences & Neurology

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art (subject category)

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By the author/editor: Chatterjee, P.; Mohammadi, M.; Goozee, K.; Shah, T. M.; Sohrabi, H. R.; Dias, C. B.; show more...; Shen, K. K.; Asih, P. R.; Dave, P.; Pedrini, S.; Ashton, Nicholas ...; Hye, A.; Taddei, K.; Lovejoy, D. B.; Zetterberg, Henr ...; Blennow, Kaj, 19 ...; Martins, R. N.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Journal of Alzhe ...

By the university: University of Gothenburg

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