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The effect of local...
The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy. A systematic review and meta-analysis.
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- Bertl, Kristina (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Division of Oral Surgery, School of Dentistry, Medical University of Vienna, Austria
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- Parllaku, Arlinda (författare)
- Private Practice, Tirana, Albania; Postgraduate Course Periodontology, Medical University of Vienna
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- Pandis, Nikolaos (författare)
- School of Dental Medicine, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland
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visa fler...
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- Buhlin, Kåre (författare)
- Karolinska Institutet
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- Klinge, Björn (författare)
- Karolinska Institutet,Malmö högskola,Odontologiska fakulteten (OD)
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- Stavropoulos, Andreas (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- Engelska.
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Ingår i: Journal of Dentistry. - : Elsevier. - 0300-5712 .- 1879-176X. ; 67, s. 18-28
- Relaterad länk:
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https://mau.diva-por... (primary) (Raw object)
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https://mau.diva-por...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives To evaluate the effect of local and/or systemic statin use as an adjunct to non-surgical and/or surgical periodontal therapy. Data Literature search according to PRISMA guidelines with the following eligibility criteria: (a) English or German language; (b) interventional studies; (c) statins as monotherapy or as an adjunct to non-surgical and/or surgical treatment of periodontitis; (d) clinical and/or radiographic treatment effect size of statin intake reported. Sources Medline (PubMed), Embase (Ovid), CENTRAL (Ovid). Study selection Thirteen clinical studies regarding local application and 2 with systemic administration of statins as an adjunct to non-surgical treatment (SRP) and 4 studies regarding intrasurgical statin application with a maximum follow-up of 9 months could be included; simvastatin, atorvastatin, and rosuvastatin were used. Local but not systemic statin application as an adjunct to SRP yielded significantly larger probing pocket depth (PD), radiographic defect depth (RDD), and bleeding index reduction, and larger clinical attachment level gain, and less residual PD and RDD (p≤0.016); rosuvastatin appeared as the most efficacious. Three of 4 studies reported a significant positive effect of intrasurgical statin application. No adverse events were reported after statin use. The vast majority of the included studies were from the same research group. Conclusions Significant additional clinical and radiographic improvements are obtained after local, but not systemic, statin use as an adjunct to SRP in deep pockets associated with intrabony defects and seemingly with furcation defects; intrasurgical statin application seems similarly beneficial. Confirmation of these results, and especially of the effect size, from other research groups is warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Atorvastatin
- clinical trials
- periodontal treatment
- rosuvastatin
- simvastatin
- statins
- systematic review
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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