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Sökning: WFRF:(Ärnlöv Johan) > (2010-2014) > Relations of circul...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004871naa a2200529 4500
001oai:DiVA.org:uu-182007
003SwePub
008121002s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:125125064
009oai:DiVA.org:du-10573
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1820072 URI
0247 a https://doi.org/10.1093/eurjhf/hfs0912 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1251250642 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-105732 URI
040 a (SwePub)uud (SwePub)kid (SwePub)du
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fall, Tove,d 1979-u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Sweden4 aut0 (Swepub:uu)tovfa878
2451 0a Relations of circulating vitamin D concentrations with left ventricular geometry and function
264 c 2014-02-27
264 1b Wiley,c 2012
338 a print2 rdacarrier
520 a Vitamin D deficiency has been associated with risk of overt cardiovascular disease (CVD), but associations with subclinical disease are not well characterized. Hence, we examined associations of circulating vitamin D concentrations and left ventricular (LV) geometry and function by echocardiography at baseline and after 5 years in a community-based study. In the PIVUS study, we measured serum 25-dihydroxyvitamin-D (25-OH D) at age 70 and performed echocardiography including LV mass, wall thickness, end-diastolic diameter, end-systolic diameter (LVESD), left atrial diameter, fractional shortening, ejection fraction, isovolumic relaxation time, and E/A ratio at both age 70 and 75. We included 870 participants (52 women) without prior myocardial infarctions, heart failure, or prevalent valvular disease. After adjusting for potential confounders, 25-OH D at baseline was found to be significantly associated with LVESD, fractional shortening, and ejection fraction (, 0.42 mm, P 0.03; , 0.70, P 0.03; and , 0.91 P 0.01, respectively), per 1 SD increase in 25-OH D (SD 20 nmol/L) at baseline. In longitudinal analyses, vitamin D levels at baseline were not significantly associated with change in LV geometry and function after 5 years. In our community-based study among the elderly, we found higher circulating vitamin D concentrations to be associated cross-sectionally with better LV systolic function and smaller LVESD at baseline. The association persisted after adjusting for several potential confounders, including cardiovascular risk factors and calcium, phosphate, and parathyroid hormone levels. Randomized clinical trials are needed to establish firmly or refute a causal relationship between vitamin D levels and changes in LV geometry and function.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Vitamin D
653 a Cardiovascular disease
653 a Biomarker
653 a Echocardiography
653 a Hälsa och välfärd
7001 a Shiue, Ivyu Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Sweden4 aut
7001 a af Geijerstam, Per Bergeau Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Sweden4 aut
7001 a Sundström, Johanu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)johasund
7001 a Ärnlöv, Johanu Högskolan Dalarna,Uppsala universitet,Geriatrik,School of Health and Social Studies, Dalarna University, Falun, Sweden,Medicinsk vetenskap4 aut0 (Swepub:du)jan
7001 a Larsson, Andersu Uppsala universitet,Biokemisk struktur och funktion4 aut0 (Swepub:uu)andlarss
7001 a Melhus, Håkanu Uppsala universitet,Klinisk farmakogenomik och osteoporos4 aut0 (Swepub:uu)hakamelh
7001 a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
7001 a Ingelsson, Eriku Karolinska Institutet4 aut0 (Swepub:uu)ering425
7102 a Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE‐171 77 Stockholm, Swedenb Kardiovaskulär epidemiologi4 org
7730 t European Journal of Heart Failured : Wileyg 14:9, s. 985-991q 14:9<985-991x 1388-9842x 1879-0844
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/eurjhf/hfs091
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182007
8564 8u https://doi.org/10.1093/eurjhf/hfs091
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125125064
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-10573

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