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Preterm prelabor ru...
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Kacerovsky, Marian
(författare)
Preterm prelabor rupture of membranes without microbial invasion of the amniotic cavity and intra-amniotic inflammation: a heterogeneous group with differences in adverse outcomes.
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2021-12-17
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Informa UK Limited,2022
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/311558
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https://gup.ub.gu.se/publication/311558URI
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https://doi.org/10.1080/14767058.2021.2017875DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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The absence of microbial invasion of the amniotic cavity and intra-amniotic inflammation at the time of hospital admission is the most common condition associated with preterm prelabor rupture of membranes (PPROM). Although the intensity of intra-amniotic inflammatory response does not exceed the threshold for the diagnosis of intra-amniotic inflammation in this subgroup of PPROM, whether there could be differences in outcomes concerning the intensity of intra-amniotic inflammatory response remains unclear. Therefore, the main aims of this study on PPROM without microbial invasion of the amniotic cavity and intra-amniotic inflammation were (i) to characterize the association between the intensity of intra-amniotic inflammatory response, measured according to amniotic fluid interleukin (IL)-6 concentrations, and the presence of acute histological chorioamnionitis and acute inflammation in the amnion; (ii) to characterize the association between the intensity of intra-amniotic inflammatory response and fetal inflammatory response, and (iii) to describe the short-term morbidity of infants based on the intensity of intra-amniotic inflammatory response.This retrospective study included 131 women with singleton pregnancies with PPROM without microbial invasion of the amniotic cavity and intra-amniotic inflammation between gestational ages of 24+0 and 36+6weeks and who had delivered within 72h of membrane rupture. Microbial invasion of the amniotic cavity was assessed based on a combination of cultivation and non-cultivation methods. Intra-amniotic inflammation was characterized based on the amniotic fluid IL-6 concentration. In addition, a histopathological assessment of the placenta was performed. Fetal inflammatory response syndrome was characterized according to IL-6 concentration in the umbilical cord blood of >11pg/mL. Based on the quartiles of IL-6 concentrations in the amniotic fluid, these women were divided into four subgroups (from the lowest to the highest IL-6 concentrations).IL-6 concentrations in amniotic fluid were higher in women with acute histological chorioamnionitis (median: 819pg/mL vs. 520pg/mL; p=.003) and with acute inflammation of the amnion (median: 1116pg/mL vs. 533pg/mL; p=.0002) than in women without these complications. The rates of acute histological chorioamnionitis and acute inflammation of the amnion were the highest in the subgroup with IL-6 concentrations above the 75th percentile in amniotic fluid (chorioamnionitis, p=.02; amnion, p=.0002). No differences in IL-6 concentrations in amniotic fluid were identified between women with and without a fetal inflammatory response syndrome (p=.40). The rate of fetal inflammatory response syndrome did not vary among the amniotic fluid IL-6 quartile subgroups of women. Moreover, no differences were noted in short-term neonatal outcomes among the amniotic fluid IL-6 quartile subgroups.A higher intensity of the intra-amniotic inflammatory response, measured by amniotic fluid IL-6 concentrations, is associated with a higher rate of acute inflammatory lesions in the placenta in the subset of PPROM pregnancies without microbial invasion of the amniotic cavity and intra-amniotic inflammation.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Matulova, Jana
(författare)
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Andrys, Ctirad
(författare)
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Mls, Jan
(författare)
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Hornychova, Helena
(författare)
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Kukla, Rudolf
(författare)
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Bostik, Pavel
(författare)
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Burckova, Hana
(författare)
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Spacek, Richard
(författare)
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Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo
(författare)
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Musilova, Ivana
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians: Informa UK Limited35:25, s. 9145-91561476-4954
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Ingår i:The Journal of Maternal-Fetal & Neonatal Medicine: Informa UK Limited35:25, s. 9145-91561476-7058
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Kacerovsky, Mari ...
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Matulova, Jana
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Andrys, Ctirad
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Mls, Jan
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Hornychova, Hele ...
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Kukla, Rudolf
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Bostik, Pavel
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Burckova, Hana
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Spacek, Richard
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Musilova, Ivana
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