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Glioma-related seiz...
Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study.
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- Berntsson, Shala G., 1964- (författare)
- Uppsala universitet,Neurologi
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Merrell, Ryan T (författare)
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Amirian, E Susan (författare)
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visa fler...
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Armstrong, Georgina N (författare)
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Lachance, Daniel (författare)
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- Smits, Anja (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Neurologi,Neurology
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Zhou, Renke (författare)
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Jacobs, Daniel I (författare)
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Wrensch, Margaret R (författare)
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Olson, Sara H (författare)
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Il'yasova, Dora (författare)
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Claus, Elizabeth B (författare)
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Barnholtz-Sloan, Jill S (författare)
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Schildkraut, Joellen (författare)
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- Melin, Beatrice S. (författare)
- Umeå universitet,Onkologi
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Johansen, Christoffer (författare)
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Houlston, Richard S (författare)
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Jenkins, Robert B (författare)
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Bernstein, Jonine L (författare)
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Lai, Rose (författare)
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Shete, Sanjay (författare)
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Amos, Christopher I (författare)
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Bondy, Melissa L (författare)
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Melin, Beatrice S (författare)
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(creator_code:org_t)
- 2018-04-23
- 2018
- Engelska.
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Ingår i: Journal of neurology. - : Springer Science and Business Media LLC. - 1432-1459 .- 0340-5354. ; 265:6, s. 1432-1442
- Relaterad länk:
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https://link.springe...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls.The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n=4533) and controls (n=4171) were also asked about seizures less than 2years from diagnosis and previous seizure history more than 2years prior to tumor diagnosis, including childhood seizures.Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p<0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood.Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Observational study (cohort
- case–control)
- Epileptic seizures
- Primary brain tumor
- Glioma-related seizures
- Observational study (cohort
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Berntsson, Shala ...
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Merrell, Ryan T
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Amirian, E Susan
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Armstrong, Georg ...
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Lachance, Daniel
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Smits, Anja
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visa fler...
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Zhou, Renke
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Jacobs, Daniel I
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Wrensch, Margare ...
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Olson, Sara H
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Il'yasova, Dora
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Claus, Elizabeth ...
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Barnholtz-Sloan, ...
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Schildkraut, Joe ...
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Melin, Beatrice ...
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Johansen, Christ ...
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Houlston, Richar ...
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Jenkins, Robert ...
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Bernstein, Jonin ...
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Lai, Rose
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Shete, Sanjay
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Amos, Christophe ...
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Bondy, Melissa L
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Melin, Beatrice ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of neuro ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet