Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in 13,087 patients.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Cederholm Jan) > (2005-2009) > Risk of cardiovascu...

Details
MARC

Eeg-Olofsson, Katarina,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in 13,087 patients.

Article/chapterEnglish2009

Publisher, publication year, extent ...

2008-11-05
Springer Science and Business Media LLC,2009

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/119191
https://gup.ub.gu.se/publication/119191URI
https://doi.org/10.1007/s00125-008-1190-xDOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103481URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

AIMS/HYPOTHESIS: The aim of this study of type 2 diabetic patients in the Swedish National Diabetes Register was to study the associations of BMI, overweight (BMI 25-29.9 kg/m(2)) and obesity (BMI >or= 30 kg/m(2)) with cardiovascular disease in type 2 diabetes, as these associations have not previously been clarified. METHODS: Patients aged 30-74 years with no previous CHD or stroke (N = 13,087) were followed for a mean of 5.6 years until 2003 for fatal or non-fatal CHD, stroke, cardiovascular disease (CHD or stroke) and total mortality. In total, 1,922 cardiovascular-disease events occurred, based on 64,864 person-years. RESULTS: The relative risks of CHD, stroke, cardiovascular disease and total mortality for a 5 unit increase in BMI at baseline were 15%, 11%, 13% and 27%, respectively, using Cox regression analysis, after adjusting for age, sex, diabetes duration, hypoglycaemic treatment and smoking (model 1), and were 9%, 4% (not significant), 7% and 20%, respectively, when adjusting also for HbA(1c), blood pressure, antihypertensive drugs, lipid-reducing drugs and microalbuminuria (model 2). Adjusted hazard ratios (model 1) for CHD, cardiovascular disease and total mortality with overweight were 1.27 (95% CI 1.09-1.48), 1.24 (1.09-1.41) and 1.16 (0.94-1.45), respectively, and 1.49 (1.27-1.76), 1.44 (1.26-1.64) and 1.71 (1.36-2.14) with obesity, as compared with normal weight. Significant hazard ratios were attenuated when adjusted according to model 2. For a 1 unit increase in BMI during follow-up, the relative risk of CHD (model 2) was 1.13 (1.04-1.23; p = 0.005). CONCLUSIONS/INTERPRETATION: Both overweight and obesity independently increased the risk of CHD and cardiovascular disease in patients with type 2 diabetes. The CHD risk was higher with increasing BMI than with stable or decreasing BMI during the study.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Adult
Aged
Blood Pressure
Body Mass Index
Cardiovascular Diseases
epidemiology
mortality
Diabetes Mellitus
Type 2
complications
drug therapy
epidemiology
mortality
Diabetic Angiopathies
epidemiology
mortality
Diet
Reducing
Humans
Hypoglycemic Agents
therapeutic use
Insulin
therapeutic use
Middle Aged
Obesity
complications
epidemiology
mortality
Overweight
complications
epidemiology
mortality
Registries
Regression Analysis
Sweden
epidemiology
BMI
MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

Cederholm, JanUppsala universitet,Allmänmedicin och klinisk epidemiologi(Swepub:uu)janceder (author)
Nilsson, P M (author)
Zethelius, BjörnUppsala universitet,Geriatrik(Swepub:uu)bjorzeth (author)
Nunez, LeylaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine (author)
Gudbjörnsdottir, Soffia,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xgudso (author)
Eliasson, Björn,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xelibj (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

In:Diabetologia: Springer Science and Business Media LLC52:1, s. 65-731432-04280012-186X

Internet link

Find in a library

Diabetologia (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Eeg-Olofsson, Ka ...; Cederholm, Jan; Nilsson, P M; Zethelius, Björn; Nunez, Leyla; Gudbjörnsdottir, ...; show more...; Eliasson, Björn, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Diabetologia

By the university: University of Gothenburg; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se