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  • Shrestha, NehaCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium (författare)

The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018
  • Royal Society of Chemistry (RSC),2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-341488
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341488URI
  • https://doi.org/10.1039/c7nr07736jDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144245URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|European Union Seventh Framework Programme (FP7) [281035]; Marie Sklodowska-Curie actions-Standard European fellowship [751257]; FNRS [J.0220.16]
  • Nanoparticulate based drug delivery systems have been extensively studied to efficiently encapsulate and deliver peptides orally. However, most of the existing data mainly focus on the nanoparticles as a drug carrier, but the ability of nanoparticles having a biological effect has not been exploited. Herein, we hypothesize that nanostructured lipid carriers (NLCs) could activate the endogenous glucagon-like peptide-1 (GLP-1) secretion and also act as oral delivery systems for GLP-1 analogs (exenatide and liraglutide). NLCs effectively encapsulated the peptides, the majority of which were only released under the intestinal conditions. NLCs, with and without peptide encapsulation, showed effective induction of GLP-1 secretion in vitro from the enteroendocrinal L-cells (GLUTag). NLCs also showed a 2.9-fold increase in the permeability of exenatide across the intestinal cell monolayer. The intestinal administration of the exenatide and liraglutide loaded NLCs did not demonstrate any glucose lowering effect on normal mice. Further, ex vivo studies depicted that the NLCs mainly adhered to the mucus layer. In conclusion, this study demonstrates that NLCs need further optimization to overcome the mucosal barrier in the intestine; nonetheless, this study also presents a promising strategy to use a dual-action drug delivery nanosystem which synergizes its own biological effect and that of the encapsulated drug molecule.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bouttefeux, OrianeCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium (författare)
  • Vanvarenberg, KevinCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium (författare)
  • Lundquist, PatrikUppsala universitet,Institutionen för farmaci,Uppsala University, Sweden(Swepub:uu)patlu774 (författare)
  • Cunarro, JuanUniv Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain (författare)
  • Tovar, SulayUniv Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain (författare)
  • Khodus, GeorgiyUppsala universitet,Institutionen för farmaci,Uppsala University, Sweden (författare)
  • Andersson, EllenVrinnevi Hosp, Dept Surg, Norrkoping, Sweden.,Vrinnevi Hospital, Sweden (författare)
  • Keita, ÅsaLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)asave24 (författare)
  • Dieguez, Carlos GonzalezUniv Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain (författare)
  • Artursson, PerUppsala universitet,Institutionen för farmaci,Uppsala University, Sweden(Swepub:uu)perartur (författare)
  • Preat, VeroniqueCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium (författare)
  • Beloqui, AnaCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium (författare)
  • Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.Catholic University of Louvain, Belgium (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nanoscale: Royal Society of Chemistry (RSC)10:2, s. 603-6132040-33642040-3372

Internetlänk

Hitta via bibliotek

  • Nanoscale (Sök värdpublikationen i LIBRIS)

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