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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005551naa a2200529 4500
001oai:DiVA.org:uu-341488
003SwePub
008180228s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-144245
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3414882 URI
0247 a https://doi.org/10.1039/c7nr07736j2 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1442452 URI
040 a (SwePub)uud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Shrestha, Nehau Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut
2451 0a The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers
264 c 2018
264 1b Royal Society of Chemistry (RSC),c 2018
338 a print2 rdacarrier
500 a Funding Agencies|European Union Seventh Framework Programme (FP7) [281035]; Marie Sklodowska-Curie actions-Standard European fellowship [751257]; FNRS [J.0220.16]
520 a Nanoparticulate based drug delivery systems have been extensively studied to efficiently encapsulate and deliver peptides orally. However, most of the existing data mainly focus on the nanoparticles as a drug carrier, but the ability of nanoparticles having a biological effect has not been exploited. Herein, we hypothesize that nanostructured lipid carriers (NLCs) could activate the endogenous glucagon-like peptide-1 (GLP-1) secretion and also act as oral delivery systems for GLP-1 analogs (exenatide and liraglutide). NLCs effectively encapsulated the peptides, the majority of which were only released under the intestinal conditions. NLCs, with and without peptide encapsulation, showed effective induction of GLP-1 secretion in vitro from the enteroendocrinal L-cells (GLUTag). NLCs also showed a 2.9-fold increase in the permeability of exenatide across the intestinal cell monolayer. The intestinal administration of the exenatide and liraglutide loaded NLCs did not demonstrate any glucose lowering effect on normal mice. Further, ex vivo studies depicted that the NLCs mainly adhered to the mucus layer. In conclusion, this study demonstrates that NLCs need further optimization to overcome the mucosal barrier in the intestine; nonetheless, this study also presents a promising strategy to use a dual-action drug delivery nanosystem which synergizes its own biological effect and that of the encapsulated drug molecule.
650 7a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng
650 7a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
7001 a Bouttefeux, Orianeu Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut
7001 a Vanvarenberg, Kevinu Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut
7001 a Lundquist, Patriku Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden4 aut0 (Swepub:uu)patlu774
7001 a Cunarro, Juanu Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain4 aut
7001 a Tovar, Sulayu Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain4 aut
7001 a Khodus, Georgiyu Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden4 aut
7001 a Andersson, Ellenu Vrinnevi Hosp, Dept Surg, Norrkoping, Sweden.,Vrinnevi Hospital, Sweden4 aut
7001 a Keita, Åsau Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US4 aut0 (Swepub:liu)asave24
7001 a Dieguez, Carlos Gonzalezu Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain4 aut
7001 a Artursson, Peru Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden4 aut0 (Swepub:uu)perartur
7001 a Preat, Veroniqueu Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut
7001 a Beloqui, Anau Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut
7102 a Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.b Catholic University of Louvain, Belgium4 org
7730 t Nanoscaled : Royal Society of Chemistry (RSC)g 10:2, s. 603-613q 10:2<603-613x 2040-3364x 2040-3372
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341488
8564 8u https://doi.org/10.1039/c7nr07736j
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144245

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