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Regional gastrointestinal contractility parameters using the wireless motility capsule : inter-observer reproducibility and influence of age, gender and study country
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- Farmer, A. D. (författare)
- Aalborg Univ, Aalborg Univ Hosp, Aalborg & Clin Inst, Mech Sense,Dept Gastroenterol & Hepatol, Aalborg, Denmark.;Queen Mary Univ London, Neurogastroenterol Grp, Ctr Neurosci & Trauma, Blizard Inst,Wingate Inst Neurogastroenterol,Bart, London, England.;Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England.
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Wegeberg, A. -ML. (författare)
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- Brock, B. (författare)
- Aarhus Univ Hosp, Dept Clin Biochem, Aarhus, Denmark.
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- Hobson, A. R. (författare)
- Funct Gut Clin, London, England.
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- Mohammed, S. D. (författare)
- Queen Mary Univ London, Neurogastroenterol Grp, Ctr Neurosci & Trauma, Blizard Inst,Wingate Inst Neurogastroenterol,Bart, London, England.
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- Scott, S. M. (författare)
- Queen Mary Univ London, Neurogastroenterol Grp, Ctr Neurosci & Trauma, Blizard Inst,Wingate Inst Neurogastroenterol,Bart, London, England.
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- Bruckner-Holt, C. E. (författare)
- Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England.
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- Semler, J. R. (författare)
- Medtronic, Sunnyvale, CA USA.
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- Hasler, W. L. (författare)
- Univ Michigan Hlth Syst, Div Gastroenterol, Ann Arbor, MI USA.
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- Hellström, Per M., 1954- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Drewes, A. M. (författare)
- Aalborg Univ, Aalborg Univ Hosp, Aalborg & Clin Inst, Mech Sense,Dept Gastroenterol & Hepatol, Aalborg, Denmark.
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- Brock, C. (författare)
- Aalborg Univ, Aalborg Univ Hosp, Aalborg & Clin Inst, Mech Sense,Dept Gastroenterol & Hepatol, Aalborg, Denmark.;Univ Copenhagen, Dept Pharmacotherapy & Dev, Copenhagen, Denmark.
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Aalborg Univ, Aalborg Univ Hosp, Aalborg & Clin Inst, Mech Sense,Dept Gastroenterol & Hepatol, Aalborg, Denmark;Queen Mary Univ London, Neurogastroenterol Grp, Ctr Neurosci & Trauma, Blizard Inst,Wingate Inst Neurogastroenterol,Bart, London, England.;Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England. Aarhus Univ Hosp, Dept Clin Biochem, Aarhus, Denmark. (creator_code:org_t)
- 2017-12-06
- 2018
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 47:3, s. 391-400
- Relaterad länk:
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http://qmro.qmul.ac....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background:The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres.Methods:Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators.Results:Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.412 vs 122 +/- 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log(e) motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times.Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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Farmer, A. D.
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Wegeberg, A. -ML ...
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Brock, B.
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Hobson, A. R.
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Mohammed, S. D.
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Scott, S. M.
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visa fler...
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Bruckner-Holt, C ...
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Semler, J. R.
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Hasler, W. L.
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Hellström, Per M ...
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Drewes, A. M.
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Brock, C.
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