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Machine learning id...
Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes
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- Choi, May Yee (författare)
- Cumming School of Medicine
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- Chen, Irene (författare)
- Massachusetts Institute of Technology
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- Clarke, Ann Elaine (författare)
- Cumming School of Medicine
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- Fritzler, Marvin J. (författare)
- Cumming School of Medicine
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- Buhler, Katherine A. (författare)
- Cumming School of Medicine
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- Urowitz, Murray (författare)
- University of Toronto
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- Hanly, John (författare)
- Dalhousie University
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- St-Pierre, Yvan (författare)
- McGill University Health Center
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Gordon, Caroline (författare)
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- Bae, Sang Cheol (författare)
- Hanyang University Hospital for Rheumatic Disease
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Romero-Diaz, Juanita (författare)
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- Sanchez-Guerrero, Jorge (författare)
- University of Toronto
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- Bernatsky, Sasha (författare)
- McGill University Health Center
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- Wallace, Daniel J. (författare)
- University of California, Los Angeles
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- Isenberg, David Alan (författare)
- University College London
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- Rahman, Anisur (författare)
- University College London
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Fortin, Paul R. (författare)
- Centre hospitalier universitaire de Québec
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- Gladman, Dafna D. (författare)
- University of Toronto
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- Bruce, Ian N. (författare)
- University of Manchester
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- Petri, Michelle (författare)
- Johns Hopkins University School of Medicine
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- Ginzler, Ellen M. (författare)
- SUNY Downstate Health Sciences University
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- Dooley, Mary Anne (författare)
- University of North Carolina
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University Feinberg School of Medicine
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- Manzi, Susan (författare)
- Allegheny Health Network
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Alarcón, Graciela S. (författare)
- University of Alabama
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- Van Vollenhoven, Ronald F. (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Aranow, Cynthia (författare)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (författare)
- Feinstein Institute for Medical Research
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Ruiz-Irastorza, Guillermo (författare)
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- Lim, Sam (författare)
- Emory University
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Inanc, Murat (författare)
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- Kalunian, Kenneth (författare)
- University of California, San Diego
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- Jacobsen, Søren (författare)
- Copenhagen University Hospital
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- Peschken, Christine (författare)
- University of Manitoba
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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Askanase, Anca (författare)
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Buyon, Jill P. (författare)
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- Sontag, David (författare)
- Massachusetts Institute of Technology
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- Costenbader, Karen H. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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(creator_code:org_t)
- 2023
- 2023
- Engelska 10 s.
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Ingår i: Annals of the Rheumatic Diseases. - 0003-4967. ; 82:7, s. 927-936
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives A novel longitudinal clustering technique was applied to comprehensive autoantibody data from a large, well-characterised, multinational inception systemic lupus erythematosus (SLE) cohort to determine profiles predictive of clinical outcomes. Methods Demographic, clinical and serological data from 805 patients with SLE obtained within 15 months of diagnosis and at 3-year and 5-year follow-up were included. For each visit, sera were assessed for 29 antinuclear antibodies (ANA) immunofluorescence patterns and 20 autoantibodies. K-means clustering on principal component analysis-transformed longitudinal autoantibody profiles identified discrete phenotypic clusters. One-way analysis of variance compared cluster enrolment demographics and clinical outcomes at 10-year follow-up. Cox proportional hazards model estimated the HR for survival adjusting for age of disease onset. Results Cluster 1 (n=137, high frequency of anti-Smith, anti-U1RNP, AC-5 (large nuclear speckled pattern) and high ANA titres) had the highest cumulative disease activity and immunosuppressants/biologics use at year 10. Cluster 2 (n=376, low anti-double stranded DNA (dsDNA) and ANA titres) had the lowest disease activity, frequency of lupus nephritis and immunosuppressants/biologics use. Cluster 3 (n=80, highest frequency of all five antiphospholipid antibodies) had the highest frequency of seizures and hypocomplementaemia. Cluster 4 (n=212) also had high disease activity and was characterised by multiple autoantibody reactivity including to antihistone, anti-dsDNA, antiribosomal P, anti-Sjögren syndrome antigen A or Ro60, anti-Sjögren syndrome antigen B or La, anti-Ro52/Tripartite Motif Protein 21, antiproliferating cell nuclear antigen and anticentromere B). Clusters 1 (adjusted HR 2.60 (95% CI 1.12 to 6.05), p=0.03) and 3 (adjusted HR 2.87 (95% CI 1.22 to 6.74), p=0.02) had lower survival compared with cluster 2. Conclusion Four discrete SLE patient longitudinal autoantibody clusters were predictive of long-term disease activity, organ involvement, treatment requirements and mortality risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- autoantibodies
- autoimmunity
- systemic lupus erythematosus
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Choi, May Yee
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Chen, Irene
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Clarke, Ann Elai ...
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Fritzler, Marvin ...
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Buhler, Katherin ...
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Urowitz, Murray
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visa fler...
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Hanly, John
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St-Pierre, Yvan
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Gordon, Caroline
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Bae, Sang Cheol
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle
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Ginzler, Ellen M ...
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Dooley, Mary Ann ...
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Ramsey-Goldman, ...
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Manzi, Susan
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Jönsen, Andreas
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Alarcón, Graciel ...
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Van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Søren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Buyon, Jill P.
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Sontag, David
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Costenbader, Kar ...
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