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Development and val...
Development and validation of a lifestyle-based model for colorectal cancer risk prediction : the LiFeCRC score
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- Aleksandrova, Krasimira (författare)
- University of Potsdam,Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH,German Institute of Human Nutrition
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- Reichmann, Robin (författare)
- University of Potsdam,German Institute of Human Nutrition
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization,Imperial College London
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- Bueno-de-Mesquita, H. Bas (författare)
- Imperial College London,National Institute for Public Health and the Environment (RIVM)
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- Dahm, Christina C. (författare)
- Aarhus University
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- Eriksen, Anne Kirstine (författare)
- Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Artaud, Fanny (författare)
- Institut Gustave Roussy,University of Paris-Saclay
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- Boutron-Ruault, Marie Christine (författare)
- Institut Gustave Roussy,University of Paris-Saclay
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- Severi, Gianluca (författare)
- Institut Gustave Roussy,University of Florence,University of Paris-Saclay
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- Hüsing, Anika (författare)
- German Cancer Research Centre
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Tumino, Rosario (författare)
- Provincial Health Authority (ASP) Ragusa
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- Elias, Sjoerd G. (författare)
- University Medical Center Utrecht
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- May, Anne M. (författare)
- University Medical Center Utrecht,Utrecht University
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- Borch, Kristin B. (författare)
- UiT The Arctic University of Norway, Tromsø
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- Sandanger, Torkjel M. (författare)
- UiT The Arctic University of Norway, Tromsø
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Sánchez, Maria Jose (författare)
- University of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Huerta, José María (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Sala, Núria (författare)
- Bellvitge Biomedical Research Institute,Catalan Institute of Oncology
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- Gurrea, Aurelio Barricarte (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Navarre Public Health Institute (ISPN),Health Research Institute of Navarra (IDISNA)
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- Quirós, José Ramón (författare)
- Public Health Directorate
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- Amiano, Pilar (författare)
- Basque Regional Health Department,CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute
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- Berntsson, Jonna (författare)
- Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Personalized Pathology & Cancer Therapy,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Drake, Isabel (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diabetes - Cardiovascular Disease,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- van Guelpen, Bethany (författare)
- Umeå universitet,Umeå University,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Harlid, Sophia (författare)
- Umeå universitet,Umeå University,Onkologi
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- Key, Tim (författare)
- University of Oxford
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Aglago, Elom K. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Cross, Amanda J. (författare)
- Imperial College London
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- Tsilidis, Konstantinos K. (författare)
- Imperial College London,University of Ioannina
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- Riboli, Elio (författare)
- Imperial College London
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2021-01-04
- 2021
- Engelska.
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Ingår i: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 19:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmcmedicine....
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to screening and motivate behaviour change. We therefore developed and validated a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population. Methods: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. The model was validated in a sample comprising 74,403 participants selected among five EPIC centres. Over a median follow-up time of 15 years, there were 3645 and 981 colorectal cancer cases in the derivation and validation samples, respectively. Variable selection algorithms in Cox proportional hazard regression and random survival forest (RSF) were used to identify the best predictors among plausible predictor variables. Measures of discrimination and calibration were calculated in derivation and validation samples. To facilitate model communication, a nomogram and a web-based application were developed. Results: The final selection model included age, waist circumference, height, smoking, alcohol consumption, physical activity, vegetables, dairy products, processed meat, and sugar and confectionary. The risk score demonstrated good discrimination overall and in sex-specific models. Harrell’s C-index was 0.710 in the derivation cohort and 0.714 in the validation cohort. The model was well calibrated and showed strong agreement between predicted and observed risk. Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data led to improved model performance overall (continuous net reclassification improvement = 0.307 (95% CI 0.264–0.352)), and especially for young individuals below 45 years (continuous net reclassification improvement = 0.364 (95% CI 0.084–0.575)). Conclusions: LiFeCRC score based on age and lifestyle data accurately identifies individuals at risk for incident colorectal cancer in European populations and could contribute to improved prevention through motivating lifestyle change at an individual level.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Cancer prevention
- Colorectal cancer
- Lifestyle behaviour
- Risk prediction
- Risk screening
- Colorectal cancer
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Aleksandrova, Kr ...
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Reichmann, Robin
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Kaaks, Rudolf
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Jenab, Mazda
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Bueno-de-Mesquit ...
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Dahm, Christina ...
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visa fler...
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Eriksen, Anne Ki ...
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Tjønneland, Anne
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Artaud, Fanny
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Boutron-Ruault, ...
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Severi, Gianluca
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Hüsing, Anika
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Peppa, Eleni
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Panico, Salvator ...
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Masala, Giovanna
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Grioni, Sara
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Sacerdote, Carlo ...
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Tumino, Rosario
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Elias, Sjoerd G.
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May, Anne M.
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Borch, Kristin B ...
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Sandanger, Torkj ...
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Skeie, Guri
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Sánchez, Maria J ...
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Huerta, José Mar ...
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Sala, Núria
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Gurrea, Aurelio ...
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Quirós, José Ram ...
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Amiano, Pilar
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Berntsson, Jonna
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Drake, Isabel
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van Guelpen, Bet ...
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Harlid, Sophia
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Key, Tim
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Weiderpass, Elis ...
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Aglago, Elom K.
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Cross, Amanda J.
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Tsilidis, Konsta ...
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Riboli, Elio
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Gunter, Marc J.
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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BMC Medicine
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Lunds universitet
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