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Prediction of non-a...
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
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- Orešič, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
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- Kotronen, Anna (författare)
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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- Gopalacharyulu, Peddinti (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Nygren, Heli (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Arola, Johanna (författare)
- Department of Pathology, HUSLAB, University of Helsinki, Helsinki, Finland
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- Castillo, Sandra (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Mattila, Ismo (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Hakkarainen, Antti (författare)
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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- Borra, Ronald J H (författare)
- Turku PET Centre, University of Turku, Turku, Finland; Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
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- Honka, Miikka-Juhani (författare)
- Turku PET Centre, University of Turku, Turku, Finland
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- Verrijken, An (författare)
- Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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- Francque, Sven (författare)
- Department of Gastroenterology and Hepatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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- Iozzo, Patricia (författare)
- Turku PET Centre, University of Turku, Turku, Finland; Institute of Clinical Physiology, National Research Council, Pisa, Italy
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- Leivonen, Marja (författare)
- Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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- Jaser, Nabil (författare)
- Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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- Juuti, Anne (författare)
- Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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- Sørensen, Thorkild I A (författare)
- Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark
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- Nuutila, Pirjo (författare)
- Turku PET Centre, University of Turku, Turku, Finland
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- Van Gaal, Luc (författare)
- Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
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- Yki-Järvinen, Hannele (författare)
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- 2013-07-04
- 2013
- Engelska.
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Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 56:10, s. 2266-2274
- Relaterad länk:
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https://doi.org/10.1...
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AIMS/HYPOTHESIS: We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.METHODS: We analysed the concentrations of molecular lipids by UPLC-MS in blood samples of 679 well-characterised individuals in whom liver-fat content was measured using proton magnetic resonance spectroscopy ((1)H-MRS) or liver biopsy. The participants were divided into biomarker-discovery (n = 287) and validation (n = 392) groups to build and validate the diagnostic models, respectively.RESULTS: Individuals with NAFLD had increased triacylglycerols with low carbon number and double-bond content while lysophosphatidylcholines and ether phospholipids were diminished in those with NAFLD. A serum-lipid signature comprising three molecular lipids ('lipid triplet') was developed to estimate the percentage of liver fat. It had a sensitivity of 69.1% and specificity of 73.8% when applied for diagnosis of NAFLD in the validation series. The usefulness of the lipid triplet was demonstrated in a weight-loss intervention study.CONCLUSIONS/INTERPRETATION: The liver-fat-biomarker signature based on molecular lipids may provide a non-invasive tool to diagnose NAFLD, in addition to highlighting lipid molecular pathways involved in the disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Lipidomics; Mass spectrometry; Non-alcoholic fatty-liver disease
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- Av författaren/redakt...
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Orešič, Matej, 1 ...
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Hyötyläinen, Tuu ...
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Kotronen, Anna
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Gopalacharyulu, ...
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Nygren, Heli
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Arola, Johanna
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Castillo, Sandra
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Mattila, Ismo
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Hakkarainen, Ant ...
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Borra, Ronald J ...
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Honka, Miikka-Ju ...
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Verrijken, An
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Francque, Sven
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Iozzo, Patricia
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Leivonen, Marja
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Jaser, Nabil
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Juuti, Anne
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Sørensen, Thorki ...
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Nuutila, Pirjo
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Van Gaal, Luc
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Yki-Järvinen, Ha ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Diabetologia
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Örebro universitet