LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature

Sökning: WFRF:(Hama R.) > LDL-C does not caus...

Introduction: For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. However, there is an increasing understanding that the mechanisms are more complicated and that statin treatment, in particular when used as primary prevention, is of doubtful benefit. Areas covered: The authors of three large reviews recently published by statin advocates have attempted to validate the current dogma. This article delineates the serious errors in these three reviews as well as other obvious falsifications of the cholesterol hypothesis. Expert commentary: Our search for falsifications of the cholesterol hypothesis confirms that it is unable to satisfy any of the Bradford Hill criteria for causality and that the conclusions of the authors of the three reviews are based on misleading statistics, exclusion of unsuccessful trials and by ignoring numerous contradictory observations.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Atherosclerosis
cardiovascular
cholesterol lowering
coronary heart disease
exposure-response
coronary-heart-disease
randomized controlled-trial
placebo-controlled
trial
density-lipoprotein cholesterol
expanded clinical-evaluation
intima-media thickness
high-dose atorvastatin
all-cause mortality
familial hypercholesterolemia
myocardial-infarction
Pharmacology & Pharmacy

de Lorgeril, M. (författare)
Diamond, D. M. (författare)
Hama, R. (författare)
Hamazaki, T. (författare)
Hammarskjold, B. (författare)
Hynes, N. (författare)
Kendrick, M. (författare)
Langsjoen, P. H. (författare)
Mascitelli, L. (författare)
McCully, K. S. (författare)
Okuyama, H. (författare)
Rosch, P. J. (författare)
Schersten, ToreGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (författare)
Sultan, S. (författare)
Sundberg, R. (författare)
Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Ingår i:Expert Review of Clinical Pharmacology: Informa UK Limited11:10, s. 959-9701751-24331751-2441

Av författaren/redakt...: Ravnskov, U.; de Lorgeril, M.; Diamond, D. M.; Hama, R.; Hamazaki, T.; Hammarskjold, B.; visa fler...; Hynes, N.; Kendrick, M.; Langsjoen, P. H.; Mascitelli, L.; McCully, K. S.; Okuyama, H.; Rosch, P. J.; Schersten, Tore; Sultan, S.; Sundberg, R.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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