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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08091naa a2200721 4500 | |
| 001 | oai:DiVA.org:liu-45434 | |
| 003 | SwePub | |
| 008 | 091011s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-454342 URI |
| 024 | 7 | a https://doi.org/10.1016/j.cub.2008.07.0492 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lao, O.u Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands4 aut |
| 245 | 1 0 | a Correlation between Genetic and Geographic Structure in Europe |
| 264 | 1 | b Elsevier BV,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry. © 2008 Elsevier Ltd. All rights reserved. | |
| 653 | a EVOL_ECOL | |
| 653 | a HUM_DISEASE | |
| 653 | a NATURAL SCIENCES | |
| 653 | a NATURVETENSKAP | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Lu, T.T.u Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Nothnagel, M.u Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Junge, O.u Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Freitag-Wolf, S.u Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Caliebe, A.u Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Balascakova, M.u Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic4 aut |
| 700 | 1 | a Bertranpetit, J.u Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain4 aut |
| 700 | 1 | a Bindoff, L.A.u Department of Neurology, Haukeland University Hospital, Institute of Clinical Medicine, 5021 Bergen, Norway4 aut |
| 700 | 1 | a Comas, D.u Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain4 aut |
| 700 | 1 | a Holmlund, Gunillau Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,National Board of Forensic Medicine, Linköping, Sweden4 aut0 (Swepub:liu)gunho29 |
| 700 | 1 | a Kouvatsi, A.u Department of Genetics, Development, and Molecular Biology, Aristotle University of Thessaloniki, GR-540 06 Thessaloniki, Greece4 aut |
| 700 | 1 | a Macek, M.u Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic4 aut |
| 700 | 1 | a Mollet, I.u Laboratoire d'Empreintes Génétiques, EFS-RA site de Lyon, 69007 Lyon, France4 aut |
| 700 | 1 | a Parson, W.u Institute of Legal Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria4 aut |
| 700 | 1 | a Palo, J.u Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland4 aut |
| 700 | 1 | a Ploski, R.u Department of Medical Genetics, Medical University Warsaw, 02-007 Warsaw, Poland4 aut |
| 700 | 1 | a Sajantila, A.u Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland4 aut |
| 700 | 1 | a Tagliabracci, A.u Istituto di Medicina Legale, University of Ancona, I-60020 Ancona, Italy4 aut |
| 700 | 1 | a Gether, U.u Molecular Neuropharmacology Group, Center for Pharmacogenomics Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark4 aut |
| 700 | 1 | a Werge, T.u Research Institute of Biological Psychiatry, Center for Pharmacogenomics, Mental Health Center Sct. Hans, DK-4000 Roskilde, Denmark4 aut |
| 700 | 1 | a Rivadeneira, F.u Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands4 aut |
| 700 | 1 | a Hofman, A.u Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands4 aut |
| 700 | 1 | a Uitterlinden, A.G.u Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands4 aut |
| 700 | 1 | a Gieger, C.u Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany4 aut |
| 700 | 1 | a Wichmann, H.-E.u Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany4 aut |
| 700 | 1 | a Ruther, A.u Rüther, A., Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Schreiber, S.u Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Becker, C.u Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany4 aut |
| 700 | 1 | a Nurnberg, P.u Nürnberg, P., Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany4 aut |
| 700 | 1 | a Nelson, M.R.u Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, United States4 aut |
| 700 | 1 | a Krawczak, M.u Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 aut |
| 700 | 1 | a Kayser, M.u Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands4 aut |
| 710 | 2 | a Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlandsb Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany4 org |
| 773 | 0 | t Current Biologyd : Elsevier BVg 18:16, s. 1241-1248q 18:16<1241-1248x 0960-9822x 1879-0445 |
| 856 | 4 | u http://www.cell.com/article/S0960982208009561/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45434 |
| 856 | 4 8 | u https://doi.org/10.1016/j.cub.2008.07.049 |
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