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  • Nerpin, Elisabet,1962-Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Lung- allergi- och sömnforskning,Klinisk fysiologi,Dalarna Univ, Dept Med Hlth & Social Studies, Falun, Sweden (författare)

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-04-14
  • Wiley,2019

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/282256
  • https://gup.ub.gu.se/publication/282256URI
  • https://doi.org/10.1111/cea.13394DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157857URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-29858URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390981URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective To identify determinants of FENO in men and women without lung diseases. Method Fractional exhaled nitric oxide was validly measured in 3881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease. Results Exhaled NO levels were 21.3% higher in men compared with women P < 0.001. Being in the upper age quartile (60.3-67.6 years), men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7-48.3 years) P = 0.02. Women in the two highest age quartiles (54.6-60.2 and 60.3-67.6 years) had 15.4 ppb (14.7, 16.2), P = 0.03 and 16.4 ppb (15.6, 17.1), P = FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (P < 0.001) and 5% higher FENO levels in women (P = 0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never-smokers (P < 0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non-sensitized subjects 26% and 29%, P Fractional exhaled nitric oxide levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Olivieri, M.Univ Verona, Unit Occupat Med, Verona, Italy (författare)
  • Gislason, T.Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland (författare)
  • Olin, Anna-Carin,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Inst Med, Sect Occupat & Environm Med, Gothenburg, Sweden(Swepub:gu)xolina (författare)
  • Nielsen, R.Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Thorac Med, Bergen, Norway (författare)
  • Johannessen, A.Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway (författare)
  • Ferreira, D. S.Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia;Univ Fed Paran, Complexo Hosp Clin, Alergia & Imunol, Curitiba, Parana, Brazil (författare)
  • Marcon, A.Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (författare)
  • Cazzoletti, L.Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (författare)
  • Accordini, S.Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (författare)
  • Pin, I.CHU Grenoble Alpes, Dept Pediat, Grenoble, France;INSERM, Inst Adv Biosci, Grenoble, France;Univ Grenoble Alpes, Grenoble, France (författare)
  • Corsico, A.IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy;Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy (författare)
  • Demoly, P.Univ Montpellier, CHU Montpellier, Hop Arnaud de Villeneuve, Dept Pneumol & Addictol, Montpellier, France;Sorbonne Univ, INSERM, Inst Pierre Louis Epidemiol & Sante Publ, Equipe EPAR, Paris, France (författare)
  • Weyler, J.Univ Antwerp, Univ Antwerp StatUA Stat Ctr, Epidemiol & Social Med, Antwerp, Belgium (författare)
  • Nowak, D.Ludwig Maximilians Univ Munchen, Hosp Ludwig Maximilian Univ Munich, Munich, Germany;German Ctr Lung Res DZL, CPC M, Munich, Germany (författare)
  • Jõgi, RainUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)raijo735 (författare)
  • Forsberg, BertilUmeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umea, Sweden(Swepub:umu)befo0001 (författare)
  • Zock, J. P.ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Madrid, Spain (författare)
  • Sigsgaard, T.Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark (författare)
  • Heinric, J.Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia (författare)
  • Bono, R.Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy (författare)
  • Leynaert, B.INSERM, UMR1152, Paris, France;Univ Paris Diderot, DHU FIRE, Paris, France (författare)
  • Jarvis, D.Imperial Coll, Natl Heart & Lung Inst, London, England (författare)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (författare)
  • Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi(Swepub:uu)anmal535 (författare)
  • European Community Resp Hlth, Surve (författare)
  • Högskolan DalarnaMedicinsk vetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical and Experimental Allergy: Wiley49:7, s. 969-9790954-78941365-2222

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