WFRF:(Khaled A)
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Synthesis of new transition metal complexes of 1H-perimidine derivatives having antimicrobial and anti-inflammatory activities
- Bassyouni, Fatma A. (author)
- Abu-Bakr, Sherifa M. (author)
- Hegab, Khaled H. (author)
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- El-Eraky, Wafaa (author)
- El Beih, Ahmed A. (author)
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- (creator_code:org_t)
- 2012-02-18
- 2012
- English.
- In: Research on chemical intermediates (Print). - : Springer Science and Business Media LLC. - 0922-6168 .- 1568-5675. ; 38:7, s. 1527-1550
- Research review (peer-reviewed)
Abstract
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- New series of 1H-perimidine-2-thiol derivatives and (2-substituted-1H-perimidin-1-yl)ethane-1,2-dione derivatives and their ligands (C24H14N4S2O2) H2L1 and (C26H18N4S2O2) H2L2 have been synthesized with transition metal ions, e.g., Copper (II), Silver (I), Cobalt (II) and Ruthenium (III) were prepared and evaluated for their antimicrobial, analgesic and anti-inflammatory activities. The synthesized compounds and their complexes were characterized by elemental analysis, H-1 NMR, IR, MS, molar conductance, thermal gravimetric analysis and electronic spectra. All results revealed that compounds 3 and 13 exhibited high inhibitory effects against some bacterial strains by the disc diffusion method. On the other hand, compounds 2, 3, 7 and 12 displayed potent anti-inflammatory activity.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Mercapto-1H-perimidine derivatives
- Quinoxaline derivatives
- Transition metal complexes
- Antiinflammatory activity
- Antimicrobial activity
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