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  • Hendrickx, Jan-JaapUniversity Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium (author)

Familial aggregation of pure tone hearing thresholds in an aging European population

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-84063
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84063URI
  • https://doi.org/10.1097/MAO.0b013e318288646aDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101453URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN: Multicenter survey in 8 European centers.SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.

Subject headings and genre

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  • Huyghe, Jeroen R.Department of Medical Genetics, University of Antwerp, Antwerp, Belgium (author)
  • Topsakal, VedatUniversity Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium (author)
  • Demeester, KellyUniversity Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium (author)
  • Wienker, Thomas F.Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany (author)
  • Laer, Lut VanUniversity of Antwerp, Belgium (author)
  • Eyken, Els VanDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (author)
  • Fransen, ErikDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium (author)
  • Mäki-Torkko, Elina,1961-Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu; and Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland(Swepub:liu)elima30 (author)
  • Hannula, SamuliInstitute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland (author)
  • Parving, AgneteDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark (author)
  • Jensen, MonaDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark (author)
  • Tropitzsch, AnkeDepartment of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany (author)
  • Bonaconsa, AmandaDepartment of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy (author)
  • Mazzoli, ManuelaDepartment of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy (author)
  • Espeso, AngelesDepartment of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK (author)
  • Verbruggen, KatjaWelsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium (author)
  • Huyghe, JokeWelsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium (author)
  • Huygen, Patrick L. M.Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre and Donders Institute for Brain, Cognition and Behaviour, the Netherlands (author)
  • Kremer, HannieDepartment of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands (author)
  • Kunst, Sylvia J.Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands (author)
  • Diaz-Lacava, Amalia N.Pharmacoepidemiology in Neurodegenerative Disorders, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany (author)
  • Steffens, MichaelInstitute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany (author)
  • Pyykkö, IlmariDepartment of Otorhinolaryngology, University of Tampere, Tampere, Finland (author)
  • Dhooge, IngeborgWelsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium (author)
  • Stephens, DafyddDepartment of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK (author)
  • Orzan, EvaAudiology and Otolaryngology Unit, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy (author)
  • Pfister, Markus H. F.Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany (author)
  • Bille, MichaelDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark (author)
  • Sorri, MarttiInstitute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland (author)
  • Cremers, Cor W. R. J.Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands (author)
  • Camp, Guy VanDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (author)
  • de Heyning, Paul VanUniversity Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium (author)
  • University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, BelgiumDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (creator_code:org_t)

Related titles

  • In:Otology and Neurotology: Lippincott Williams & Wilkins34:5, s. 838-8441531-71291537-4505

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