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Sökning: WFRF:(Lahesmaa Riitta) > Coxsackievirus B1 R...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003215naa a2200445 4500
001oai:DiVA.org:uu-231114
003SwePub
008140904s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2311142 URI
0247 a https://doi.org/10.1002/jmv.239032 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hamalainen, Sanna4 aut
2451 0a Coxsackievirus B1 Reveals Strain Specific Differences in Plasmacytoid Dendritic Cell Mediated Immunogenicity
264 c 2014-02-20
264 1b Wiley,c 2014
338 a print2 rdacarrier
520 a Enterovirus infections are usually mild but can also cause severe illnesses and play a role in chronic diseases, such as cardiomyopathies and type 1 diabetes. Host response to the invading virus can markedly modulate the course of the infection, and this response varies between individuals due to the polymorphism of immune response genes. However, it is currently not known if virus strains also differ in their ability to stimulate the host immune system. Coxsackievirus B1 (CBV1) causes severe epidemics in young infants and it has recently been connected with type 1 diabetes in seroepidemiological studies. This study evaluated the ability of different field isolates of CBV1 to induce innate immune responses in PBMCs. CBV1 strains differed markedly in their capacity to induce innate immune responses. Out of the 18 tested CBV1 strains two induced exceptionally strong alpha interferon (IFN-alpha) response in PBMC cultures. The responding cell type was found to be the plasmacytoid dendritic cell. Such a strong innate immune response was accompanied by an up-regulation of several other immune response genes and secretion of cytokines, which modulate inflammation, and adaptive immune responses. These results suggest that enterovirus-induced immune activation depends on the virus strain. It is possible that the immunotype of the virus modulates the course of the infection and plays a role in the pathogenesis of chronic immune-mediated enterovirus diseases.  
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653 a coxsackievirus B1 (CBV1)
653 a innate immunity
653 a interferon-alpha (IFN-alpha)
653 a pDC
7001 a Nurminen, Noora4 aut
7001 a Ahlfors, Helena4 aut
7001 a Oikarinen, Sami4 aut
7001 a Sioofy-Khojine, Amir-Babak4 aut
7001 a Frisk, Gunu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)gunfrisk
7001 a Oberste, M. Steven4 aut
7001 a Lahesmaa, Riitta4 aut
7001 a Pesu, Marko4 aut
7001 a Hyoty, Heikki4 aut
7102 a Uppsala universitetb Klinisk immunologi4 org
7730 t Journal of Medical Virologyd : Wileyg 86:8, s. 1412-1420q 86:8<1412-1420x 0146-6615x 1096-9071
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231114
8564 8u https://doi.org/10.1002/jmv.23903

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