Search: WFRF:(Lindahl U)
> (2020-2024) >
Randomized comparis...
Randomized comparison of early supplemental oxygen versus ambient air in patients with confirmed myocardial infarction : Sex-related outcomes from DETO2X-AMI
-
- Alfredsson, Joakim, 1962- (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Dept Cardiol, Linköping, Sweden.
-
- James, Stefan, 1964- (author)
- Uppsala universitet,Uppsala University,Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Institutionen för kirurgiska vetenskaper,Klinisk fysiologi
-
- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden.
-
show more...
-
- Herlitz, Johan, 1949- (author)
- University of Borås,Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,PreHospen,Department of Health Sciences, University of Borås, Borås, Sweden,Univ Borås, Dept Hlth Sci, Borås, Sweden.
-
- Fröbert, Ole, 1964- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Cardiol, Örebro, Sweden.
-
- Dworeck, Christian (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Univ Gothenburg, Dept Cardiol, Sahlgrenska Univ Hosp, Gothenburg, Sweden.,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
- Redfors, Björn (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Univ Gothenburg, Dept Cardiol, Sahlgrenska Univ Hosp, Gothenburg, Sweden.,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
- Arefalk, Gabriel (author)
- Uppsala University,Uppsala Univ, Sweden
-
- Östlund, O. (author)
- Uppsala universitet,Uppsala University,Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.,Institutionen för kirurgiska vetenskaper
-
- Jernberg, T. (author)
- Karolinska Institutet,Karolinska Institute,Danderyd Hospital,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Cardiol, Stockholm, Sweden.
-
- Mars, K. (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital,Karolinska Inst, Sodersjukhuset, Div Cardiol, Dept Clin Sci & Educ, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
-
- Haaga, U. (author)
- Department of Cardiology, Karlstad Central Hospital, Karlstad, Sweden,Karlstad Cent Hosp, Dept Cardiol, Karlstad, Sweden.
-
- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
- Swahn, Eva (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Dept Cardiol, Linköping, Sweden.
-
- Sederholm Lawesson, Sofia (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Dept Cardiol, Linköping, Sweden.
-
- Hofmann, R. (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital,Karolinska Inst, Sodersjukhuset, Div Cardiol, Dept Clin Sci & Educ, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
-
Investigators, for the DETO2X-SWEDEHEART (author)
-
Alfredsson, Johan (author)
-
show less...
-
(creator_code:org_t)
- Mosby Inc. 2021
- 2021
- English.
-
In: American Heart Journal. - : Mosby Inc.. - 0002-8703 .- 1097-6744. ; 237, s. 13-24
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://hb.diva-port... (primary) (Raw object)
-
https://doi.org/10.1...
-
http://dx.doi.org/10... (free)
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- Background: The purpose of this study is to investigate the impact of oxygen therapy on cardiovascular outcomes in relation to sex in patients with confirmed myocardial infarction (MI).Methods: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction trial randomized 6,629 patients to oxygen at 6 L/min for 6-12 hours or ambient air. In the present subgroup analysis including 5,010 patients (1,388 women and 3,622 men) with confirmed MI, we report the effect of supplemental oxygen on the composite of all-cause death, rehospitalization with MI, or heart failure at long-term follow-up, stratified according to sex.Results: Event rate for the composite endpoint was 18.1% in women allocated to oxygen, compared to 21.4% in women allocated to ambient air (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.65-1.05). In men, the incidence was 13.6% in patients allocated to oxygen compared to 13.3% in patients allocated to ambient air (HR 1.03, 95% CI 0.86-1.23). No significant interaction in relation to sex was found (P=.16). Irrespective of allocated treatment, the composite endpoint occurred more often in women compared to men (19.7 vs 13.4%, HR 1.51; 95% CI, 1.30-1.75). After adjustment for age alone, there was no difference between the sexes (HR 1.06, 95% CI 0.91-1.24), which remained consistent after multivariate adjustment.Conclusion: Oxygen therapy in normoxemic MI patients did not significantly affect all-cause mortality or rehospitalization for MI or heart failure in women or men. The observed worse outcome in women was explained by differences in baseline characteristics, especially age
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- acetylsalicylic acid
- angiotensin receptor antagonist
- beta adrenergic receptor blocking agent
- calcium channel blocking agent
- clopidogrel
- dipeptidyl carboxypeptidase inhibitor
- diuretic agent
- oxygen
- prasugrel
- ticagrelor
- acute heart infarction
- adult
- aged
- all cause mortality
- ambient air
- Article
- cardiovascular function
- cause of death
- clinical outcome
- comparative study
- controlled study
- female
- follow up
- heart failure
- hospital readmission
- hospitalization
- human
- incidence
- long term care
- major clinical study
- male
- outcome assessment
- oxygen saturation
- oxygen supply
- oxygen therapy
- population
- priority journal
- randomized controlled trial
- sex difference
- ST segment elevation myocardial infarction
- treatment indication
- Människan i vården
- The Human Perspective in Care
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Alfredsson, Joak ...
-
James, Stefan, 1 ...
-
Erlinge, David
-
Herlitz, Johan, ...
-
Fröbert, Ole, 19 ...
-
Dworeck, Christi ...
-
show more...
-
Redfors, Björn
-
Arefalk, Gabriel
-
Östlund, O.
-
Jernberg, T.
-
Mars, K.
-
Haaga, U.
-
Lindahl, Bertil, ...
-
Swahn, Eva
-
Sederholm Lawess ...
-
Hofmann, R.
-
Investigators, f ...
-
Alfredsson, Joha ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
American Heart J ...
- By the university
-
University of Borås
-
Örebro University
-
Lund University
-
Karolinska Institutet
-
Linköping University
-
Uppsala University
-
show more...
-
University of Gothenburg
-
show less...