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Real-world diagnost...
Real-world diagnostic accuracy and use of immunohistochemical markers in lung cancer diagnostics
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- Lindquist, Kajsa Ericson (författare)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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- Gudinaviciene, Inga (författare)
- Region Skåne
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- Mylona, Nektaria (författare)
- Region Skåne
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- Urdar, Rodrigo (författare)
- Region Skåne
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- Lianou, Maria (författare)
- Region Skåne
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- Darai-Ramqvist, Eva (författare)
- Karolinska University Hospital
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- Haglund, Felix (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Béndek, Mátyás (författare)
- Karolinska University Hospital
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- Bardoczi, Erika (författare)
- Karolinska University Hospital
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- Dobra, Katalin (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Brunnström, Hans (författare)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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(creator_code:org_t)
- 2021-11-18
- 2021
- Engelska.
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Ingår i: Biomolecules. - : MDPI AG. - 2218-273X. ; 11:11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: Accurate and reliable diagnostics are crucial as histopathological type influ-ences selection of treatment in lung cancer. The aim of this study was to evaluate real-world accuracy and use of immunohistochemical (IHC) staining in lung cancer diagnostics. Materials and Methods: The diagnosis and used IHC stains for small specimens with lung cancer on follow-up resection were retrospectively investigated for a 15-month period at two major sites in Sweden. Additionally, 10 pathologists individually suggested diagnostic IHC staining for 15 scanned bronchial and lung biopsies and cytological specimens. Results: In 16 (4.7%) of 338 lung cancer cases, a discordant diagnosis of potential clinical relevance was seen between a small specimen and the fol-low-up resection. In half of the cases, there was a different small specimen from the same investi-gational work-up with a concordant diagnosis. Diagnostic inaccuracy was often related to a squa-mous marker not included in the IHC panel (also seen for the scanned cases), the case being a neu-roendocrine tumor, thyroid transcription factor-1 (TTF-1) expression in squamous cell carcinomas (with clone SPT24), or poor differentiation. IHC was used in about 95% of cases, with a higher number of stains in biopsies and in squamous cell carcinomas and especially neuroendocrine tumors. Pre-surgical transthoracic samples were more often diagnostic than bronchoscopic ones (72–85% vs. 9–53% for prevalent types). Conclusions: Although a high overall diagnostic accuracy of small specimens was seen, small changes in routine practice (such as consequent inclusion of p40 and TTF-1 clone 8G7G3/1 in the IHC panel for non-small cell cancer with unclear morphology) may lead to improvement, while reducing the number of IHC stains would be preferable from a time and cost perspective.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Biopsy
- Bronchoscopy
- Cytology
- Sampling
- Transthoracic
- TTF-1
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lindquist, Kajsa ...
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Gudinaviciene, I ...
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Mylona, Nektaria
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Urdar, Rodrigo
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Lianou, Maria
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Darai-Ramqvist, ...
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visa fler...
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Haglund, Felix
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Béndek, Mátyás
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Bardoczi, Erika
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Dobra, Katalin
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Brunnström, Hans
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Biomolecules
- Av lärosätet
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Lunds universitet
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Karolinska Institutet