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Implementing a novel capture and ligation probe-PCR method in mass screen and treatment to support malaria elimination efforts in the China-Myanmar border region
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- Sun, Xiao-dong (författare)
- Yunnan Prov Ctr Malaria Res, Yunnan Inst Parasit Dis, Yunnan Prov Collaborat Innovat Ctr Publ Hlth & Dis, Yunnan Prov Key Lab Vector borne Dis Control & Res, Puer 665000, Peoples R China.
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- Zhao, Ya-ling (författare)
- Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China.;Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China.
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- Lin, Zu-rui (författare)
- Yunnan Prov Ctr Malaria Res, Yunnan Inst Parasit Dis, Yunnan Prov Collaborat Innovat Ctr Publ Hlth & Dis, Yunnan Prov Key Lab Vector borne Dis Control & Res, Puer 665000, Peoples R China.
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- Yunnan Prov Ctr Malaria Res, Yunnan Inst Parasit Dis, Yunnan Prov Collaborat Innovat Ctr Publ Hlth & Dis, Yunnan Prov Key Lab Vector borne Dis Control & Res, Puer 665000, Peoples R China Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China.;Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China. (creator_code:org_t)
- 2023-01-19
- 2023
- Engelska.
- Ingår i: Malaria Journal. - : BioMed Central (BMC). - 1475-2875. ; 22:1
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- BackgroundMass screening and treatment (MSAT) for malaria elimination lacks an ideal diagnostic tool to allow sensitive and affordable test of the target population in the field. This study evaluated whether Capture and Ligation Probe-PCR (CLIP-PCR) could be used in a field MSAT in Laiza City, Myanmar.MethodsOn day 0, two dried blood spots were collected from each participant. On day 1, all samples were screened for Plasmodium in a 20 m(2) laboratory with workbench, a biosafety cabinet, a refrigerator, a benchtop shaking incubator and a qPCR machine, by four technicians using CLIP-PCR with sample pooling, at a health clinic of the Chinese bordering town of Nabang. On day 2, all positives were followed up and treated.ResultsOf 15,038 persons (65% of the total population) screened, 204 (1.36%) were CLIP-PCR positives. Among them, 188, 14, and 2 were infected with Plasmodium vivax, Plasmodium falciparum, and P. vivax/P. falciparum mix, respectively. The testing capacity was 538 persons/day, with a cost of US$0.92 /person. The proportion of submicroscopic infection was 64.7%. All positive individuals received treatment within 72 h after blood collection.ConclusionUsing CLIP-PCR in MSAT in low transmission settings can support the malaria elimination efforts in the China-Myanmar border region.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Malaria
- Mass screening and treatment
- Capture and ligation probe-PCR
- Submicroscopic
- Field application
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- Sun, Xiao-dong
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- Zheng, Zhi
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