Sökning: WFRF:(Muschiol Sandra) >
Persistence of sali...
Persistence of salivary antibody responses after COVID-19 vaccination is associated with oral microbiome variation in both healthy and people living with HIV
-
- Ghorbani, Mahin (författare)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
-
- Al-Manei, Khaled (författare)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;King Saud Univ, Coll Dent, Dept Restorat Dent Sci, Riyadh, Saudi Arabia.
-
- Naud, Sabrina (författare)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
-
visa fler...
-
- Healy, Katie (författare)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Karolinska Inst, Dept Lab Med, Huddinge, Sweden.
-
- Gabarrini, Giorgio (författare)
- Karolinska Institutet
-
- Sobkowiak, Michal Jacek (författare)
- Karolinska Institutet
-
- Chen, Puran (författare)
- Karolinska Inst, Dept Med, Huddinge, Sweden.
-
- Ray, Shilpa (författare)
- Karolinska Institutet
-
- Akber, Mira (författare)
- Karolinska Inst, Dept Med, Huddinge, Sweden.
-
- Muschiol, Sandra (författare)
- Karolinska Institutet
-
- Bogdanovic, Gordana (författare)
- Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
-
- Bergman, Peter (författare)
- Karolinska Institutet
-
- Ljungman, Per (författare)
- Karolinska Institutet
-
- Buggert, Marcus (författare)
- Karolinska Institutet
-
- Ljunggren, Hans-Gustaf (författare)
- Karolinska Inst, Dept Med, Huddinge, Sweden.
-
- Pin, Elisa (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
-
- Nowak, Piotr (författare)
- Karolinska Institutet
-
- Aleman, Soo (författare)
- Karolinska Institutet
-
- Saellberg Chen, Margaret (författare)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
-
visa färre...
-
Karolinska Inst, Dept Dent Med, Huddinge, Sweden Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;King Saud Univ, Coll Dent, Dept Restorat Dent Sci, Riyadh, Saudi Arabia. (creator_code:org_t)
- 2023-01-10
- 2023
- Engelska.
-
Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 13
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Coevolution of microbiome and immunity at mucosal sites is essential for our health. Whether the oral microbiome, the second largest community after the gut, contributes to the immunogenicity of COVID-19 vaccines is not known. We investigated the baseline oral microbiome in individuals in the COVAXID clinical trial receiving the BNT162b2 mRNA vaccine. Participants (n=115) included healthy controls (HC; n=57) and people living with HIV (PLHIV; n=58) who met the study selection criteria. Vaccine-induced Spike antibodies in saliva and serum from 0 to 6 months were assessed and comparative analyses were performed against the individual salivary 16S ASV microbiome diversity. High- versus low vaccine responders were assessed on general, immunological, and oral microbiome features. Our analyses identified oral microbiome features enriched in high- vs. low-responders among healthy and PLHIV participants. In low-responders, an enrichment of Gram-negative, anaerobic species with proteolytic activity were found including Campylobacter, Butyrivibrio, Selenomonas, Lachnoanaerobaculum, Leptotrichia, Megasphaera, Prevotella and Stomatobaculum. In high-responders, enriched species were mainly Gram-positive and saccharolytic facultative anaerobes: Abiotrophia, Corynebacterium, Gemella, Granulicatella, Rothia, and Haemophilus. Combining identified microbial features in a classifier using the area under the receiver operating characteristic curve (ROC AUC) yielded scores of 0.879 (healthy controls) to 0.82 (PLHIV), supporting the oral microbiome contribution in the long-term vaccination outcome. The present study is the first to suggest that the oral microbiome has an impact on the durability of mucosal immunity after Covid-19 vaccination. Microbiome-targeted interventions to enhance long-term duration of mucosal vaccine immunity may be exploited.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Oral microbiome
- mRNA vaccination
- saliva
- SARS-CoV-2
- campylobacter
- leptotrichia
- gemella
- granulicatella
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ghorbani, Mahin
-
Al-Manei, Khaled
-
Naud, Sabrina
-
Healy, Katie
-
Gabarrini, Giorg ...
-
Sobkowiak, Micha ...
-
visa fler...
-
Chen, Puran
-
Ray, Shilpa
-
Akber, Mira
-
Muschiol, Sandra
-
Bogdanovic, Gord ...
-
Bergman, Peter
-
Ljungman, Per
-
Buggert, Marcus
-
Ljunggren, Hans- ...
-
Pin, Elisa
-
Nowak, Piotr
-
Aleman, Soo
-
Saellberg Chen, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
- Artiklar i publikationen
-
Frontiers in Imm ...
- Av lärosätet
-
Kungliga Tekniska Högskolan
-
Karolinska Institutet