Sökning: WFRF:(Nilsson Maria E)
> (2020-2024) >
Interaction between...
Interaction between gad65 antibodies and dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acids on incident adult-onset diabetes : The epic-interact study
-
- Löfvenborg, Josefin E. (författare)
- Karolinska Institutet,Karolinska Institute
-
- Carlsson, Sofia (författare)
- Karolinska Institutet,Karolinska Institute
-
- Andersson, Tomas (författare)
- Karolinska Institutet,Stockholm County Council,Karolinska Institute
-
visa fler...
-
- Hampe, Christiane S. (författare)
- University of Washington
-
- Koulman, Albert (författare)
- University of Cambridge
-
- Lopez, María Dolores Chirlaque (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),University of Murcia
-
- Jakszyn, Paula (författare)
- L'Hospitalet de Llobregat, Barcelona,Ramon Llull University
-
- Katzke, Verena A. (författare)
- German Cancer Research Centre
-
- Kühn, Tilman (författare)
- German Cancer Research Centre
-
- Kyrø, Cecilie (författare)
- Danish Cancer Society
-
- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
-
- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
- Overvad, Kim (författare)
- Aalborg University Hospital,Aarhus University
-
- Panico, Salvatore (författare)
- University of Naples Federico II
-
- Sánchez, Maria Jose (författare)
- University of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
-
- Van Der Schouw, Yvonne (författare)
- University Medical Center Utrecht
-
- Schulze, Matthias B. (författare)
- University of Potsdam,German Center for Diabetes Research,German Institute of Human Nutrition
-
- Tjønneland, Anne (författare)
- Danish Cancer Society,University of Copenhagen
-
- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
-
- Riboli, Elio (författare)
- Imperial College London
-
- Forouhi, Nita G. (författare)
- University of Cambridge
-
- Sharp, Stephen J. (författare)
- University of Cambridge
-
- Rolandsson, Olov (författare)
- Umeå universitet,Umeå University,Allmänmedicin
-
- Wareham, Nicholas J. (författare)
- University of Cambridge
-
visa färre...
-
(creator_code:org_t)
- 2020-12-10
- 2021
- Engelska 9 s.
-
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 44:2, s. 416-424
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://care.diabete...
-
https://lup.lub.lu.s...
-
https://doi.org/10.2...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes. RESEARCH DESIGN AND METHODS: We used prospective data on 11,247 incident cases of adult-onset diabetes and 14,288 noncases from the EPIC-InterAct case-cohort study conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction [AP]) and multiplicative interactions between GAD65 antibody positivity (≥65 units/mL) and low fish/n-3 PUFA were assessed. RESULTS: The hazard of diabetes in antibody-positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52 [95% CI 1.76-3.63] and 2.48 [1.79-3.45]) compared with people who were GAD65 antibody negative and had high fish intake, with evidence of additive (AP 0.44 [95% CI 0.16-0.72] and 0.48 [0.24-0.72]) and multiplicative (P 5 0.0465 and 0.0103) interactions. Individuals with high GAD65 antibody levels (≥167.5 units/mL) and low total plasma phospholipid n-3 PUFAs had a more than fourfold higher hazard of diabetes (HR 4.26 [2.70-6.72]) and an AP of 0.46 (0.12-0.80) compared with antibody-negative individuals with high n-3 PUFAs. CONCLUSIONS: High fish intake or relative plasma phospholipid n-3 PUFA concentrations may partially counteract the increased diabetes risk conferred by GAD65 antibody positivity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Löfvenborg, Jose ...
-
Carlsson, Sofia
-
Andersson, Tomas
-
Hampe, Christian ...
-
Koulman, Albert
-
Lopez, María Dol ...
-
visa fler...
-
Jakszyn, Paula
-
Katzke, Verena A ...
-
Kühn, Tilman
-
Kyrø, Cecilie
-
Masala, Giovanna
-
Nilsson, Peter M ...
-
Overvad, Kim
-
Panico, Salvator ...
-
Sánchez, Maria J ...
-
Van Der Schouw, ...
-
Schulze, Matthia ...
-
Tjønneland, Anne
-
Weiderpass, Elis ...
-
Riboli, Elio
-
Forouhi, Nita G.
-
Sharp, Stephen J ...
-
Rolandsson, Olov
-
Wareham, Nichola ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
- Artiklar i publikationen
-
Diabetes Care
- Av lärosätet
-
Lunds universitet
-
Umeå universitet
-
Karolinska Institutet