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Cytokines in gingiv...
Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study : RANTES was associated with periodontitis
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- Söderlin, Maria K. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, SWE
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- Persson, Gösta Rutger (författare)
- University of Washington, SWE,USA
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- Renvert, Stefan (författare)
- Kristianstad University,Blekinge Institute of Technology,Blekinge Tekniska Högskola,Institutionen för hälsa,Trinity College Dublin,University of Hong Kong,Oral Health - Public Health - Quality of Life (OHAL),Department of Oral Health,Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL),Avdelningen för oral hälsa
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- Sanmartin Berglund, Johan, Professor (författare)
- Blekinge Institute of Technology,Blekinge Tekniska Högskola,Institutionen för hälsa
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(creator_code:org_t)
- 2021-05-05
- 2021
- Engelska.
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Ingår i: Journal of Periodontal Research. - : Blackwell Munksgaard. - 0022-3484 .- 1600-0765. ; 56:5, s. 907-916
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Abstract
Ämnesord
Stäng
- Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question. Results: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p =.049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis. © 2021 The Authors. Journal of Periodontal Research published by John Wiley & Sons Ltd.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- cytokines
- gingival crevicular fluid
- periodontitis
- rheumatoid arthritis
- cytokines
- gingival crevicular fluid
- periodontitis
- rheumatoid arthritis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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