SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Petrova Tatiana V.)
 

Sökning: WFRF:(Petrova Tatiana V.) > Mechanotransduction...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002650naa a2200433 4500
001oai:DiVA.org:uu-287143
003SwePub
008160422s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2871432 URI
0247 a https://doi.org/10.1016/j.devcel.2011.12.0202 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sabine, Amélie4 aut
2451 0a Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.
264 1b Elsevier BV,c 2012
338 a print2 rdacarrier
520 a Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early lymphatic-valve morphogenesis and the role of biomechanical forces are not well understood. We found that the transcription factors PROX1 and FOXC2, highly expressed from the onset of valve formation, mediate segregation of lymphatic-valve-forming cells and cell mechanosensory responses to shear stress in vitro. Mechanistically, PROX1, FOXC2, and flow coordinately control expression of the gap junction protein connexin37 and activation of calcineurin/NFAT signaling. Connexin37 and calcineurin are required for the assembly and delimitation of lymphatic valve territory during development and for its postnatal maintenance. We propose a model in which regionally increased levels/activation states of transcription factors cooperate with mechanotransduction to induce a discrete cell-signaling pattern and morphogenetic event, such as formation of lymphatic valves. Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction.
7001 a Agalarov, Yan4 aut
7001 a Maby-El Hajjami, Hélène4 aut
7001 a Jaquet, Muriel4 aut
7001 a Hägerling, René4 aut
7001 a Pollmann, Cathrin4 aut
7001 a Bebber, Damien4 aut
7001 a Pfenniger, Anna4 aut
7001 a Miura, Naoyuki4 aut
7001 a Dormond, Olivier4 aut
7001 a Calmes, Jean-Marie4 aut
7001 a Adams, Ralf H4 aut
7001 a Mäkinen, Taija4 aut
7001 a Kiefer, Friedemann4 aut
7001 a Kwak, Brenda R4 aut
7001 a Petrova, Tatiana V4 aut
7730 t Developmental Celld : Elsevier BVg 22:2q 22:2x 1534-5807x 1878-1551
8564 u http://www.cell.com/article/S1534580711005867/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-287143
8564 8u https://doi.org/10.1016/j.devcel.2011.12.020

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy