CARD15/NOD2 polymorphisms do not explain concordance of Crohn´s disease in Swedish monozygotic twins

Halfvarson, Jonas,1970-Division of Gastroenterology, Department of Internal Medicine, Orebro University Hospital, Orebro, Sweden (author)

BACKGROUND: CARD15/NOD2 polymorphisms are associated with Crohn's disease. There is a high concordance for disease and disease phenotype in monozygotic twin pairs with Crohn's disease.AIM: We studied CARD15/NOD2 polymorphisms in a Swedish, population-based cohort of monozygotic twins with Crohn's disease to assess whether these variants explain disease concordance.SUBJECTS AND METHODS: Twenty-nine monozygotic twin pairs (concordant n=9, discordant n=20) with Crohn's disease and 192 healthy controls were investigated for the CARD15/NOD2 variants Arg702Trp, Gly908Arg and Leu1007fsinsC.RESULTS: CARD15/NOD2 mutations were found in 5/38 (13%) twins with Crohn's disease, corresponding to a total allele frequency of 6.6%. Only 2/9 concordant twin pairs carried any of the variants and the remaining seven were wild type genotype. The total allele frequency was 4.4 times higher (95% confidence interval 1.0-21.5, p=0.06) in concordant twins than in discordant ones, 11.1% versus 2.5%. In healthy controls the total allele frequency was 2.6%.CONCLUSIONS: CARD15/NOD2 polymorphisms contribute but do not alone explain concordance of Crohn's disease in monozygotic twins and, at least in a Swedish population, other polymorphisms are required. The low occurrence of CARD15/NOD2 mutations in the study and other Northern European populations suggests that these variants are of less importance in Northern Europe.

Bresso, FKarolinska Institutet,IRIS Center, Karolinska Institute-MTC, Stockholm, Sweden (author)
D ´Amato, MKarolinska Institutet,IRIS Center, Karolinska Institute-MTC, Stockholm, Sweden (author)
Järnerot, GDivision of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden (author)
Pettersson, SKarolinska Institutet,IRIS Center, Karolinska Institute-MTC, Stockholm, Sweden (author)
Tysk, CDivision of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden (author)
Karolinska InstitutetDivision of Gastroenterology, Department of Internal Medicine, Orebro University Hospital, Orebro, Sweden (creator_code:org_t)

By the author/editor: Halfvarson, Jona ...; Bresso, F; D ´Amato, M; Järnerot, G; Pettersson, S; Tysk, C

About the subject

By the university: Örebro University; Karolinska Institutet; Linköping University

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