Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue

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Rentoft, MatildaUmeå universitet,Kemiska institutionen,Patologi (författare)

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue

Artikel/kapitelEngelska2014

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2014-01-07
Springer Science and Business Media LLC,2014
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-92407
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92407URI
https://doi.org/10.1007/s13277-013-1549-6DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216228URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets. Lately, much focus has been set on immunomodulation as a possible treatment or an adjuvant increasing sensitivity to conventional treatments. The objective of this study was to evaluate the prognostic importance of response to radiotherapy in tongue carcinoma patients as well as the expression of the CXC-chemokines in correlation to radiation response in the same group of tumours. Thirty-eight patients with tongue carcinoma that had received radiotherapy followed by surgery were included. The prognostic impact of pathological response to radiotherapy, N-status, T-stage, age and gender was evaluated using Cox's regression models, Kaplan-Meier survival curves and chi-square test. The expression of 23 CXC-chemokine ligands and their receptors were evaluated in all patients using microarray and qPCR and correlated with response to treatment using logistic regression. Pathological response to radiotherapy was independently associated to overall survival with a 2-year survival probability of 81% for patients showing a complete pathological response, while patients with a non-complete response only had a probability of 42% to survive for 2 years (p = 0.016). The expression of one CXC-chemokine, CXCL10, was significantly associated with response to radiotherapy and the group of patients with the highest CXCL10 expression responded, especially poorly (p = 0.01). CXCL10 is a potential marker for response to radiotherapy and overall survival in patients with squamous cell carcinoma of the tongue.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
p63
prognosis
tongue carcinoma

Biuppslag (personer, institutioner, konferenser, titlar ...)

Coates, Philip JohnUniv Dundee, Ninewells Hosp & Med Sch, Tayside Tissue Bank, Med Res Inst, Dundee DD1 9SY, Scotland (författare)
Loljung, LottaUmeå universitet,Patologi(Swepub:umu)loalut02 (författare)
Wilms, TorbenUmeå universitet,Öron- näs- och halssjukdomar(Swepub:umu)towi0017 (författare)
Laurell, GöranUppsala universitet,Umeå universitet,Patologi,Univ Uppsala Hosp, Dept Surg Sci ENT, S-75185 Uppsala, Sweden,Öron-, näs- och halssjukdomar(Swepub:uu)gorla772 (författare)
Nylander, KarinUmeå universitet,Patologi(Swepub:umu)kaanyr77 (författare)
Umeå universitetKemiska institutionen (creator_code:org_t)

Sammanhörande titlar

Ingår i:Tumor Biology: Springer Science and Business Media LLC35:5, s. 4191-41981010-42831423-0380

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Tumor Biology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Rentoft, Matilda; Coates, Philip J ...; Loljung, Lotta; Wilms, Torben; Laurell, Göran; Nylander, Karin

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Tumor Biology

Av lärosätet: Umeå universitet; Uppsala universitet

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