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A Randomized Trial of Endometrial Scratching before In Vitro Fertilization
- Lensen, S. (author)
- Osavlyuk, D. (author)
- Armstrong, S. (author)
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- Hennes, A. (author)
- Napier, E. (author)
- Wilkinson, J. (author)
- Sadler, L. (author)
- Gupta, D. (author)
- Vigneswaran, K. (author)
- Teh, W. T. (author)
- Hamoda, H. (author)
- Webber, L. (author)
- Wakeman, S. A. (author)
- Searle, L. (author)
- Bhide, P. (author)
- McDowell, S. (author)
- Peeraer, K. (author)
- Khalaf, Y. (author)
- Farquhar, C. (author)
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- (creator_code:org_t)
- 2019
- 2019
- English.
- In: New England Journal of Medicine. - 0028-4793. ; 380:4, s. 325-334
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation and increase the probability of pregnancy in women undergoing in vitro fertilization (IVF). We conducted a pragmatic, multicenter, open-label, randomized, controlled trial. Eligible women were undergoing IVF (fresh-embryo or frozen-embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e.g., hysteroscopy). Participants were randomly assigned in a 1: 1 ratio to either endometrial scratching (by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle) or no intervention. The primary outcome was live birth. A total of 1364 women underwent randomization. The frequency of live birth was 180 of 690 women (26.1%) in the endometrial-scratch group and 176 of 674 women (26.1%) in the control group (adjusted odds ratio, 1.00; 95% confidence interval, 0.78 to 1.27). There were no significant between-group differences in the rates of ongoing pregnancy, clinical pregnancy, multiple pregnancy, ectopic pregnancy, or miscarriage. The median score for pain from endometrial scratching (on a scale of 0 to 10, with higher scores indicating worse pain) was 3.5 (interquartile range, 1.9 to 6.0). Endometrial scratching did not result in a higher rate of live birth than no intervention among women undergoing IVF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- live-birth-rates
- pregnancy rate
- implantation failure
- embryo-transfer
- injury
- women
- metaanalyses
- inflammation
- infertility
- outcomes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Lensen, S.
- Osavlyuk, D.
- Armstrong, S.
- Stadelmann, Caro ...
- Hennes, A.
- Napier, E.
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- Wilkinson, J.
- Sadler, L.
- Gupta, D.
- Strandell, Annik ...
- Bergh, Christina ...
- Vigneswaran, K.
- Teh, W. T.
- Hamoda, H.
- Webber, L.
- Wakeman, S. A.
- Searle, L.
- Bhide, P.
- McDowell, S.
- Peeraer, K.
- Khalaf, Y.
- Farquhar, C.
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- University of Gothenburg
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