Sökning: WFRF:(Shields Denis C.) > Pharmacogenetic met...
Fältnamn | Indikatorer | Metadata |
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000 | 07441naa a2201633 4500 | |
001 | oai:gup.ub.gu.se/207817 | |
003 | SwePub | |
008 | 240910s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:d95a45f6-c850-43c3-8ecc-22aceb449b61 | |
024 | 7 | a https://gup.ub.gu.se/publication/2078172 URI |
024 | 7 | a https://doi.org/10.1038/ncomms60682 DOI |
024 | 7 | a https://lup.lub.lu.se/record/47330122 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Postmus, Iris4 aut |
245 | 1 0 | a Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. |
264 | c 2014-10-28 | |
264 | 1 | b Springer Science and Business Media LLC,c 2014 |
520 | a Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Trompet, Stella4 aut |
700 | 1 | a Deshmukh, Harshal A4 aut |
700 | 1 | a Barnes, Michael R4 aut |
700 | 1 | a Li, Xiaohui4 aut |
700 | 1 | a Warren, Helen R4 aut |
700 | 1 | a Chasman, Daniel I4 aut |
700 | 1 | a Zhou, Kaixin4 aut |
700 | 1 | a Arsenault, Benoit J4 aut |
700 | 1 | a Donnelly, Louise A4 aut |
700 | 1 | a Wiggins, Kerri L4 aut |
700 | 1 | a Avery, Christy L4 aut |
700 | 1 | a Griffin, Paula4 aut |
700 | 1 | a Feng, QiPing4 aut |
700 | 1 | a Taylor, Kent D4 aut |
700 | 1 | a Li, Guo4 aut |
700 | 1 | a Evans, Daniel S4 aut |
700 | 1 | a Smith, Albert V4 aut |
700 | 1 | a de Keyser, Catherine E4 aut |
700 | 1 | a Johnson, Andrew D4 aut |
700 | 1 | a de Craen, Anton J M4 aut |
700 | 1 | a Stott, David J4 aut |
700 | 1 | a Buckley, Brendan M4 aut |
700 | 1 | a Ford, Ian4 aut |
700 | 1 | a Westendorp, Rudi G J4 aut |
700 | 1 | a Eline Slagboom, P4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Munroe, Patricia B4 aut |
700 | 1 | a Sever, Peter4 aut |
700 | 1 | a Poulter, Neil4 aut |
700 | 1 | a Stanton, Alice4 aut |
700 | 1 | a Shields, Denis C4 aut |
700 | 1 | a O'Brien, Eoin4 aut |
700 | 1 | a Shaw-Hawkins, Sue4 aut |
700 | 1 | a Ida Chen, Y-D4 aut |
700 | 1 | a Nickerson, Deborah A4 aut |
700 | 1 | a Smith, Joshua D4 aut |
700 | 1 | a Pierre Dubé, Marie4 aut |
700 | 1 | a Matthijs Boekholdt, S4 aut |
700 | 1 | a Kees Hovingh, G4 aut |
700 | 1 | a Kastelein, John J P4 aut |
700 | 1 | a McKeigue, Paul M4 aut |
700 | 1 | a Betteridge, John4 aut |
700 | 1 | a Neil, Andrew4 aut |
700 | 1 | a Durrington, Paul N4 aut |
700 | 1 | a Doney, Alex4 aut |
700 | 1 | a Carr, Fiona4 aut |
700 | 1 | a Morris, Andrew4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Ahlqvist, Emmau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah |
700 | 1 | a Bis, Joshua C4 aut |
700 | 1 | a Rice, Kenneth4 aut |
700 | 1 | a Smith, Nicholas L4 aut |
700 | 1 | a Lumley, Thomas4 aut |
700 | 1 | a Whitsel, Eric A4 aut |
700 | 1 | a Stürmer, Til4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Ngwa, Julius S4 aut |
700 | 1 | a O'Donnell, Christopher J4 aut |
700 | 1 | a Vasan, Ramachandran S4 aut |
700 | 1 | a Wei, Wei-Qi4 aut |
700 | 1 | a Wilke, Russell A4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Sun, Fangui4 aut |
700 | 1 | a Guo, Xiuqing4 aut |
700 | 1 | a Heckbert, Susan R4 aut |
700 | 1 | a Post, Wendy4 aut |
700 | 1 | a Sotoodehnia, Nona4 aut |
700 | 1 | a Arnold, Alice M4 aut |
700 | 1 | a Stafford, Jeanette M4 aut |
700 | 1 | a Ding, Jingzhong4 aut |
700 | 1 | a Herrington, David M4 aut |
700 | 1 | a Kritchevsky, Stephen B4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Launer, Leonore J4 aut |
700 | 1 | a Harris, Tamara B4 aut |
700 | 1 | a Chu, Audrey Y4 aut |
700 | 1 | a Giulianini, Franco4 aut |
700 | 1 | a MacFadyen, Jean G4 aut |
700 | 1 | a Barratt, Bryan J4 aut |
700 | 1 | a Nyberg, Fredrik,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine4 aut0 (Swepub:gu)xnybef |
700 | 1 | a Stricker, Bruno H4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Emilsson, Valur4 aut |
700 | 1 | a Franco, Oscar H4 aut |
700 | 1 | a Ridker, Paul M4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Denny, Joshua C4 aut |
700 | 1 | a Ballantyne, Christie M4 aut |
700 | 1 | a Rotter, Jerome I4 aut |
700 | 1 | a Adrienne Cupples, L4 aut |
700 | 1 | a Psaty, Bruce M4 aut |
700 | 1 | a Palmer, Colin N A4 aut |
700 | 1 | a Tardif, Jean-Claude4 aut |
700 | 1 | a Colhoun, Helen M4 aut |
700 | 1 | a Hitman, Graham4 aut |
700 | 1 | a Krauss, Ronald M4 aut |
700 | 1 | a Wouter Jukema, J4 aut |
700 | 1 | a Caulfield, Mark J4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 5q 5x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/ncomms6068.pdf |
856 | 4 | u https://portal.research.lu.se/files/3175361/7525881x primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25350695?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/ncomms6068y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/207817 |
856 | 4 8 | u https://doi.org/10.1038/ncomms6068 |
856 | 4 8 | u https://lup.lub.lu.se/record/4733012 |
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