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Estimating cardiac ...
Estimating cardiac mechanical efficiency in a porcine ex situ working heart model
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- Pigot, Harry (författare)
- Lund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Artificiell intelligens och bioinformatik inom thoraxkirurgisk vetenskap,Forskargrupper vid Lunds universitet,LTH profilområde: AI och digitalisering,LTH profilområden,LTH profilområde: Teknik för hälsa,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS),Lund University Research Groups,LTH Profile Area: AI and Digitalization,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,Faculty of Engineering, LTH
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- Steen, Stig (författare)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups
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- Soltesz, Kristian (författare)
- Lund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,LTH profilområde: AI och digitalisering,LTH profilområden,LTH profilområde: Teknik för hälsa,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,Heart and Lung transplantation,Lund University Research Groups,LTH Profile Area: AI and Digitalization,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: IFAC Proceedings Volumes (IFAC-PapersOnline). - 2405-8963.
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Abstract
Ämnesord
Stäng
- We introduce a method for assessing cardiac mechanical efficiency via a porcine ex situ biventricular working heart model, designed to closely replicate physiological conditions and improve the evaluation of donor heart viability for transplantation. The method aims to provide decision support for the safe utilization of hearts that might otherwise be discarded. Quantifying the heart’s pumping work against its chemical energy yield, our model advances traditional assessments by incorporating dynamic flow impedances to simulate real-world cardiac loads. We calculate mechanical efficiency by measuring aortic pressure, cardiac output, coronary flow, and blood-gas parameters in six porcine hearts beating in isolation, outside of the body, against computer-controlled dynamic flow impedances. The observed mean mechanical efficiency was 8.0±0.8 % (standard error of the mean), below the physiological norm of 25 %. This discrepancy underscores the influence of ex situ conditions on heart performance, as well as the limitations of standard estimation methods. Impacts of the ex situ setup as well as estimation improvements are discussed. Future research will explore integrating imaging technologies (MRI) to refine mechanical efficiency assessment.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Reglerteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Control Engineering (hsv//eng)
Nyckelord
- artificial organs and biomechanical systems
- decision support systems
- cardiac mechanical efficiency
- biomedical system modelling
- ex situ working heart model
- functional heart assessment
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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