Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells

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Fältnamn	Indikatorer	Metadata
000		03604naa a2200373 4500
001		oai:DiVA.org:umu-106777
003		SwePub
008		150807s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:131641139
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1067772 URI
024	7	a https://doi.org/10.1038/srep122872 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1316411392 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lopes, Jose Pedro,d 1986-u Umeå universitet,Klinisk bakteriologi,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)jolo0034
245	1 0	a Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells
264		c 2015-07-20
264	1	b Nature Publishing Group,c 2015
338		a print2 rdacarrier
520		a Immunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal, colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. Mast cells are present in tissues prone to fungal colonization being expectedly among the first immune cells to get into contact with C. albicans. However, mast cell-fungus interaction remains a neglected area of study. Here we show that human mast cells mounted specific responses towards C. albicans. Collectively, mast cell responses included the launch of initial, intermediate and late phase components determined by the secretion of granular proteins and cytokines. Initially mast cells reduced fungal viability and occasionally internalized yeasts. C. albicans could evade ingestion by intracellular growth leading to cellular death. Furthermore, secreted factors in the supernatants of infected cells recruited neutrophils, but not monocytes. Late stages were marked by the release of cytokines that are known to be anti-inflammatory suggesting a modulation of initial responses. C. albicans-infected mast cells formed extracellular DNA traps, which ensnared but did not kill the fungus. Our results suggest that mast cells serve as tissue sentinels modulating antifungal immune responses during C. albicans infection. Consequently, these findings open new doors for understanding fungal pathogenicity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
700	1	a Stylianou, Marios,d 1981-u Umeå universitet,Klinisk bakteriologi,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR)4 aut0 (Swepub:umu)mast0120
700	1	a Nilsson, Gunnaru Karolinska Institutet4 aut
700	1	a Urban, Constantin F.u Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Klinisk bakteriologi4 aut0 (Swepub:umu)cour0001
710	2	a Umeå universitetb Klinisk bakteriologi4 org
773	0	t Scientific Reportsd : Nature Publishing Groupg 5q 5x 2045-2322
856	4	u https://www.nature.com/articles/srep12287.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106777
856	4 8	u https://doi.org/10.1038/srep12287
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:131641139

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