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Splenomegaly versus...
Splenomegaly versus pathological lung volume during COVID-19 infection with or without cytokine storm; a linear regression analysis using CT volumetry
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- Samir, A. (författare)
- Alexandria Univ, Fac Med, Dept Radiol, Alexandria, Egypt.
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- Gharraf, H. S. (författare)
- Alexandria Univ, Fac Med, Dept Chest Dis, Alexandria, Egypt.
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- Baess, A. I. (författare)
- Alexandria Univ, Fac Med, Dept Chest Dis, Alexandria, Egypt.
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- Sweed, R. A. (författare)
- Alexandria Univ, Fac Med, Dept Chest Dis, Alexandria, Egypt.
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- Matrawy, K. (författare)
- Alexandria Univ, Med Res Inst, Dept Radiol, Alexandria, Egypt.
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- Geijer, Mats, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Radiol, Gothenburg, Sweden.
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- Shalabi, Adel (författare)
- Uppsala universitet,Radiologi
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- Tarek, Y. (författare)
- Alexandria Univ, Fac Med, Dept Radiol, Alexandria, Egypt.
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Alexandria Univ, Fac Med, Dept Radiol, Alexandria, Egypt Alexandria Univ, Fac Med, Dept Chest Dis, Alexandria, Egypt. (creator_code:org_t)
- 2022-05-19
- 2022
- Engelska.
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Ingår i: Egyptian Journal of Radiology and Nuclear Medicine. - : Springer Science and Business Media LLC. - 2090-4762. ; 53:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Due to the paucity of scientific evidence, it is unclear among pulmonologists and physicians in critical care units if and when splenomegaly in novel coronavirus disease (2019) (COVID-19) patients is worrisome. This study aims to evaluate the significance of splenic volume during COVID-19 infection with or without cytokine storm and correlates splenic volume to the volume of pathological lung changes through linear regression analysis. Results: A retrospective study collected 509 polymerase chain reaction proved COVID-19 patients (399 males, 110 females; mean age 48 years, age range 24-78 years) between June and November 2021, without a history of splenic pathology. A control group of age and sex-matched 509 healthy subjects was used and analyzed according to the splenic volume. Five consulting radiologists evaluated initial and follow-up computed tomography (CT) examinations using lung CT volumetry and splenic volume calculation in consensus. Three consulting pulmonologists correlated the severity of clinical and laboratory findings, including oxygen requirements and interleukin-6 (IL-6) levels. The T test results for comparison between the COVID-19 patients and the healthy subjects control group regarding the splenic volume were significant (Tvalue was - 4.731452 and p value was 0.00002). There was no significant correlation between the severity of the disease and normal-sized spleen (26% of patients, p= 0.916) or splenomegaly (24% of patients, p= 0.579). On the other hand, all patients with a small spleen or progressive splenomegaly during serial follow-up imaging had clinically severe disease with a statistically significant correlation (p= 0.017 and 0.003, respectively). Ninety-seven percent of patients with clinically mild disease and splenomegaly had 0-20% lung involvement (CT-severity score 1) while all patients with clinically severe disease and splenomegaly had 27-73% lung involvement (CT-severity score 2 and 3) (r = 0.305, p = 0.030). Conclusions: Splenomegaly is a non-specific sign that may be found during mild and severe COVID-19 infection, it was not statistically correlated with the clinical severity and a weak positive relationship was found between the splenic size and the CT-severity score of the pathological lung volume. On the other hand, the presence of splenic atrophy or progressive splenomegaly was correlated with severe COVID-19 presentation and "cytokine storm". Therefore, the splenic volume changes should not be overlooked in COVID-19 serial CT examinations, particularly in severe or critically ill patients with cytokine storms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- COVID
- Splenomegaly
- Cytokine
- spleen
- Radiology
- Nuclear Medicine & Medical Imaging
- COVID
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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