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Polysomnographic ch...
Polysomnographic characteristics of excessive daytime sleepiness phenotypes in obstructive sleep apnea : results from the international sleep apnea global interdisciplinary consortium
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- Thorarinsdottir, Elin H. (författare)
- Dept Family Med, Primary Hlth Care Capital Area, Reykjavik, Iceland.;Univ Iceland, Fac Med, Dept Med, Reykjavik, Iceland.;Univ Iceland, Fac Med, IS-108 Reykjavik, Iceland.;Primary Hlth Care Capital Area, IS-108 Reykjavik, Iceland.
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- Pack, Allan, I (författare)
- Univ Penn, Perelman Sch Med, Dept Med, Div Sleep Med, Philadelphia, PA USA.
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- Gislason, Thorarinn (författare)
- Univ Iceland, Fac Med, Dept Med, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Sleep Dept, Landspitali, Reykjavik, Iceland.
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- Kuna, Samuel T. (författare)
- Corporal Michael J Crescenz VA Med Ctr, Dept Med, Philadelphia, PA USA.
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- Penzel, Thomas (författare)
- Charite, Interdisciplinary Ctr Sleep Med, Berlin, Germany.
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- Li, Qing Yun (författare)
- Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp & Crit Care Med, Shanghai, Peoples R China.
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- Cistulli, Peter A. (författare)
- Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW, Australia.;Royal North Shore Hosp, Dept Resp & Sleep Med, St Leonards, NSW, Australia.
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- Magalang, Ulysses J. (författare)
- Ohio State Univ, Wexner Med Ctr, Div Pulm Crit Care & Sleep Med, Columbus, OH USA.
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- McArdle, Nigel (författare)
- Sir Charles Gairdner Hosp, West Australian Sleep Disorders Res Inst, Nedlands, WA, Australia.;Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA, Australia.
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- Singh, Bhajan (författare)
- Sir Charles Gairdner Hosp, West Australian Sleep Disorders Res Inst, Nedlands, WA, Australia.;Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA, Australia.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Aspelund, Thor (författare)
- Univ Iceland, Fac Med, Dept Med, Reykjavik, Iceland.;Iceland Heart Assoc, Kopavogur, Iceland.
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- Younes, Magdy (författare)
- Univ Manitoba, Sleep Disorders Ctr, Dept Med, Winnipeg, MB, Canada.
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- de Chazal, Philip (författare)
- Univ Sydney, Fac Engn, Charles Perkins Ctr, Sydney, NSW, Australia.
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- Tufik, Sergio (författare)
- Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil.
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- Keenan, Brendan T. (författare)
- Univ Penn, Perelman Sch Med, Dept Med, Div Sleep Med, Philadelphia, PA USA.
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Dept Family Med, Primary Hlth Care Capital Area, Reykjavik, Iceland;Univ Iceland, Fac Med, Dept Med, Reykjavik, Iceland.;Univ Iceland, Fac Med, IS-108 Reykjavik, Iceland.;Primary Hlth Care Capital Area, IS-108 Reykjavik, Iceland. Univ Penn, Perelman Sch Med, Dept Med, Div Sleep Med, Philadelphia, PA USA. (creator_code:org_t)
- Oxford University Press, 2024
- 2024
- Engelska.
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Ingår i: Sleep. - : Oxford University Press. - 0161-8105 .- 1550-9109. ; 47:4
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Study Objectives: Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnea (OSA). Traditional polysomnographic (PSG) measures only partially explain EDS in OSA. This study analyzed traditional and novel PSG characteristics of two different measures of EDS among patients with OSA. Methods: Sleepiness was assessed using the Epworth Sleepiness Scale (>10 points defined as "risk of dozing") and a measure of general sleepiness (feeling sleepy >= 3 times/week defined as "feeling sleepy"). Four sleepiness phenotypes were identified: "non-sleepy," "risk of dozing only," "feeling sleepy only," and "both at risk of dozing and feeling sleepy." Results: Altogether, 2083 patients with OSA (69% male) with an apnea-hypopnea index (AHI) >= 5 events/hour were studied; 46% were "non-sleepy," 26% at "risk of dozing only," 7% were "feeling sleepy only," and 21% reported both. The two phenotypes at "risk of dozing" had higher AHI, more severe hypoxemia (as measured by oxygen desaturation index, minimum and average oxygen saturation [SpO(2)], time spent < 90% SpO(2), and hypoxic impacts) and they spent less time awake, had shorter sleep latency, and higher heart rate response to arousals than "non-sleepy" and "feeling sleepy only" phenotypes. While statistically significant, effect sizes were small. Sleep stages, frequency of arousals, wake after sleep onset and limb movement did not differ between sleepiness phenotypes after adjusting for confounders. Conclusions: In a large international group of patients with OSA, PSG characteristics were weakly associated with EDS. The physiological measures differed among individuals characterized as "risk of dozing" or "non-sleepy," while "feeling sleepy only" did not differ from "non-sleepy" individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Excessive daytime sleepiness
- obstructive sleep apnea
- polysomnography
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Thorarinsdottir, ...
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Pack, Allan, I
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Gislason, Thorar ...
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Kuna, Samuel T.
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Penzel, Thomas
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Li, Qing Yun
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visa fler...
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Cistulli, Peter ...
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Magalang, Ulysse ...
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McArdle, Nigel
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Singh, Bhajan
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Janson, Christer
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Aspelund, Thor
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Younes, Magdy
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de Chazal, Phili ...
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Tufik, Sergio
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Keenan, Brendan ...
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