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The association bet...
The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent
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Jacobs, Heidi I. L. (author)
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Visser, Pieter Jelle (author)
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Van Boxtel, Martin P. J. (author)
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Frisoni, Giovanni B. (author)
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Tsolaki, Magda (author)
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Papapostolou, Panagiota (author)
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Nobili, Flavio (author)
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- Wahlund, Lars-Olof (author)
- Karolinska Institutet
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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Frolich, Lutz (author)
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Hampel, Harald (author)
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Soininen, Hilkka (author)
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van de Pol, Laura (author)
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Scheltens, Philip (author)
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Tan, Frans E. S. (author)
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Jolles, Jelle (author)
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Verhey, Frans R. J. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 33:1, s. 1-201
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the frontal-parietal-subcortical network were associated with decline in executive functioning. However, the frontal-subcortical network was not associated with change in executive functioning. Our results suggest that parietal WMH are a significant contributor to executive decline in MCI and that investigation of WMH in the cerebral networks supporting cognitive functions provide a new way to differentiate stable from cognitive declining MCI individuals. (C) 2012 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Mild cognitive impairment
- White matter hyperintensities
- Executive
- function
- Frontoparietal circuit
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jacobs, Heidi I. ...
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Visser, Pieter J ...
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Van Boxtel, Mart ...
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Frisoni, Giovann ...
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Tsolaki, Magda
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Papapostolou, Pa ...
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show more...
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Nobili, Flavio
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Wahlund, Lars-Ol ...
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Minthon, Lennart
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Frolich, Lutz
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Hampel, Harald
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Soininen, Hilkka
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van de Pol, Laur ...
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Scheltens, Phili ...
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Tan, Frans E. S.
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Jolles, Jelle
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Verhey, Frans R. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurobiology of ...
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Lund University
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Karolinska Institutet