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Effects of cohort, ...
Effects of cohort, genotype, variant, and maternal β-blocker treatment on foetal heart rate predictors of inherited long QT syndrome
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- Kaizer, Alexander M. (författare)
- Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Anschutz Medical Campus, CO, Aurora, United States
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- Winbo, Annika (författare)
- Umeå universitet,Pediatrik,Department of Physiology, University of Auckland, Auckland, New Zealand
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- Clur, Sally-Ann B (författare)
- Department of Pediatric Cardiology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands; Department of Cardiology, University Medical Center, Amsterdam, Netherlands
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- Etheridge, Susan P. (författare)
- Department of Pediatrics, Division of Cardiology, University of Utah School of Medicine, UT, Salt Lake City, United States
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- Ackerman, Michael J. (författare)
- Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, MN, Rochester, United States; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, MN, Rochester, United States; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, MN, Rochester, United States; Mayo Clinic, Windland Smith Rice Genetic Heart Rhythm Clinic and Windland Smith Rice Sudden Death Genomics Laboratory, MN, Rochester, United States
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- Horigome, Hitoshi (författare)
- Department of Pediatrics, Section of Cardiology, Tsukuba University, Tsukuba, Japan
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- Herberg, Ulrike (författare)
- Department of Pediatric Cardiology, RWTH University Hospital Aachen, Aachen, Germany; Department of Pediatric Cardiology, University Hospital Bonn, Bonn, Germany
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- Dagradi, Federica (författare)
- Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Via Pier Lombardo 22, Milan, Italy
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- Spazzolini, Carla (författare)
- Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Via Pier Lombardo 22, Milan, Italy
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- Killen, Stacy A S (författare)
- Department of Pediatrics, Division of Cardiology, Vanderbilt University Medical Center, TN, Nashville, United States
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- Wacker-Gussmann, Annette (författare)
- Department of Congenital Heart Disease and Paediatric Cardiology, German Heart Center, Munich, Germany
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- Wilde, Arthur A M (författare)
- Department of Cardiology, University Medical Center, Amsterdam, Netherlands; Department of Cardiology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands; Department of Cardiology, Amseterdam University Medical Center, Amsterdam, Netherlands
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- Sinkovskaya, Elena (författare)
- Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Eastern Virginia Medical School, VA, Norfolk, United States
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- Abuhamad, Alfred (författare)
- Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Eastern Virginia Medical School, VA, Norfolk, United States
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- Torchio, Margherita (författare)
- Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Via Pier Lombardo 22, Milan, Italy
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- Ng, Chai-Ann (författare)
- Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia; School of Clinical Medicine, UNSW Sydney, Darlinghurst, NSW, Australia
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- Rydberg, Annika (författare)
- Umeå universitet,Pediatrik,Department of Cardiology, University Medical Center, Amsterdam, Netherlands
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- Schwartz, Peter J. (författare)
- Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Via Pier Lombardo 22, Milan, Italy
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- Cuneo, Bettina F. (författare)
- Department of Pediatrics, Section of Cardiology, University of Denver School of Medicine, 13123 16th Ave, Box 100, Aurora, CO 80045, USA
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(creator_code:org_t)
- Oxford University Press, 2023
- 2023
- Engelska.
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Ingår i: Europace. - : Oxford University Press. - 1099-5129 .- 1532-2092. ; 25:11
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- AIMS: In long QT syndrome (LQTS), primary prevention improves outcome; thus, early identification is key. The most common LQTS phenotype is a foetal heart rate (FHR) < 3rd percentile for gestational age (GA) but the effects of cohort, genotype, variant, and maternal β-blocker therapy on FHR are unknown. We assessed the influence of these factors on FHR in pregnancies with familial LQTS and developed a FHR/GA threshold for LQTS.METHODS AND RESULTS: In an international cohort of pregnancies in which one parent had LQTS, LQTS genotype, familial variant, and maternal β-blocker effects on FHR were assessed. We developed a testing algorithm for LQTS using FHR and GA as continuous predictors. Data included 1966 FHRs at 7-42 weeks' GA from 267 pregnancies/164 LQTS families [220 LQTS type 1 (LQT1), 35 LQTS type 2 (LQT2), and 12 LQTS type 3 (LQT3)]. The FHRs were significantly lower in LQT1 and LQT2 but not LQT3 or LQTS negative. The LQT1 variants with non-nonsense and severe function loss (current density or β-adrenergic response) had lower FHR. Maternal β-blockers potentiated bradycardia in LQT1 and LQT2 but did not affect FHR in LQTS negative. A FHR/GA threshold predicted LQT1 and LQT2 with 74.9% accuracy, 71% sensitivity, and 81% specificity.CONCLUSION: Genotype, LQT1 variant, and maternal β-blocker therapy affect FHR. A predictive threshold of FHR/GA significantly improves the accuracy, sensitivity, and specificity for LQT1 and LQT2, above the infant's a priori 50% probability. We speculate this model may be useful in screening for LQTS in perinatal subjects without a known LQTS family history.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Bradycardia
- Channelopathy
- Foetal arrhythmia
- Foetus
- Inherited arrhythmias
- Long QT syndrome
- Potassium currents
- Stillbirth
- Sudden death
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Kaizer, Alexande ...
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Winbo, Annika
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Clur, Sally-Ann ...
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Etheridge, Susan ...
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Ackerman, Michae ...
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Horigome, Hitosh ...
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Herberg, Ulrike
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Dagradi, Federic ...
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Spazzolini, Carl ...
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Killen, Stacy A ...
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Wacker-Gussmann, ...
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Wilde, Arthur A ...
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Sinkovskaya, Ele ...
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Abuhamad, Alfred
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Torchio, Margher ...
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Ng, Chai-Ann
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Rydberg, Annika
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Schwartz, Peter ...
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Cuneo, Bettina F ...
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