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Overlapping stimula...
Overlapping stimulation of subthalamic nucleus and dentato-rubro-thalamic tract in Parkinson's disease after deep brain stimulation
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- Wisniewski, K. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
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- Gajos, A. (författare)
- Med Univ Lodz, Dept Extrapyramidal Dis, Lodz, Poland.
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- Zaczkowski, K. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
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- Szulia, A. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
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- Grzegorczyk, M. (författare)
- Med Univ Warsaw, Dept Descript & Clin Anat, Warsaw, Poland.
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- Dabkowska, A. (författare)
- Med Univ Warsaw, Dept Forens Med, Warsaw, Poland.
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- Wojcik, R. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
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- Bobeff, E. J. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.;Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
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- Kwiecien, K. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
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- Brandel, M. G. (författare)
- Univ Calif San Diego, Dept Neurosurg, San Diego, CA 92123 USA.
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- Fahlström, Andreas (författare)
- Uppsala universitet,Neurokirurgi
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- Bogucki, A. (författare)
- Med Univ Lodz, Dept Extrapyramidal Dis, Lodz, Poland.
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- Ciszek, B. (författare)
- Med Univ Warsaw, Dept Descript & Clin Anat, Warsaw, Poland.
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- Jaskolski, D. J. (författare)
- Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
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Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland Med Univ Lodz, Dept Extrapyramidal Dis, Lodz, Poland. (creator_code:org_t)
- Springer, 2024
- 2024
- Engelska.
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Ingår i: Acta Neurochirurgica. - : Springer. - 0001-6268 .- 0942-0940. ; 166:1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces tremor, rigidity, and akinesia. According to the literature, the dentato-rubro-thalamic tract (DRTt) is verified target for DBS in essential tremor; however, its role in the treatment of Parkinson's disease is only vaguely described. The aim of our study was to identify the relationship between symptom alleviation in PD patients and the distance of the DBS electrode electric field (EF) to the DRTt.MethodsA single-center retrospective analysis of patients (N = 30) with idiopathic Parkinson's disease (PD) who underwent DBS between November 2018 and January 2020 was performed. DRTt and STN were visualized using diffusion-weighted imaging (DWI) and tractography protocol of magnetic resonance (MR). The EF was calculated and compared with STN and course of DRTt. Evaluation of patients before and after surgery was performed with use of UPDRS-III scale. The association between distance from EF to DRTt and clinical outcomes was examined. To confirm the anatomical variation between DRTt and STN observed in tractography, white matter dissection was performed with the Klingler technique on ten human brains.ResultsPatients with EF overlapping STN and DRTt benefited from significant motor symptoms improvement. Anatomical findings confirmed the presence of population differences in variability of the DRTt course and were consistent with the DRTt visualized by MR.ConclusionsDRTt proximity to STN, the main target in PD DBS surgery, confirmed by DWI with tractography protocol of MR combined with proper predefined stimulation parameters may improve efficacy of DBS-STN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Deep brain stimulation
- Parkinson disease
- Dento-rubro-thalamic tract
- Tractopgraphy
- Klingler technique
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wisniewski, K.
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Gajos, A.
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Zaczkowski, K.
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Szulia, A.
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Grzegorczyk, M.
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Dabkowska, A.
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visa fler...
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Wojcik, R.
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Bobeff, E. J.
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Kwiecien, K.
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Brandel, M. G.
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Fahlström, Andre ...
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Bogucki, A.
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Ciszek, B.
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Jaskolski, D. J.
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