Search: WFRF:(den Ruijter Hester M) >
Circulating GDF-15 ...
Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis
-
- Gohar, Aisha (author)
- University Medical Center Utrecht
-
- Gonçalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies,Skåne University Hospital
-
- Vrijenhoek, Joyce (author)
- University Medical Center Utrecht
-
show more...
-
- Haitjema, Saskia (author)
- University Medical Center Utrecht
-
- van Koeverden, Ian (author)
- University Medical Center Utrecht
-
- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
-
- de Borst, Gert J. (author)
- University Medical Center Utrecht
-
- de Vries, Jean-Paul P. M. (author)
- St. Antonius Hospital
-
- Pasterkamp, Gerard (author)
- University Medical Center Utrecht
-
- den Ruijter, Hester M (author)
- University Medical Center Utrecht
-
- Björkbacka, Harry (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups
-
- de Jager, Saskia C A (author)
- University Medical Center Utrecht
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
-
In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 241, s. 430-436
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
http://www.internati...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases.We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated with carotid plaque characteristics. Methods: Circulating GDF-15 levels were determined by Luminex assay in a cohort of 1056 patients from the Athero-Express biobank. Composite endpoint was defined as major CVE, death and peripheral vascular interventions. Findings were validated in 473 patients from the independent Carotid Plaque Imaging Project biobank. Results: GDF-15 levels did not associate with secondary CVE in the total cohort. However, following a significant interaction with sex, it was found to be strongly, independently predictive of secondary CVE in women but not men (quartile 4 vs. quartile 1: HR 3.04 [95% CI 1.35-6.86], p = 0.007 in women vs. HR 0.96 [95% CI 0.66-1.40], p = 0.845 in men). This was also observed in the validation cohort (women: HR 2.28 [95% CI 1.04-5.05], p = 0.041), albeit dependent upon renal function. In addition, GDF-15 was associated with the presence of plaque smooth muscle cells and calcification. Conclusion: High circulating GDF-15 levels are predictive of secondary CVE in women but not in men with carotid atherosclerotic disease undergoing CEA, suggesting a potential use for GDF-15 as a biomarker for secondary prevention in women. Sex differences in the role of GDF-15 in atherosclerotic disease deserve further interest.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Atherosclerosis
- Biomarker
- GDF-15
- Prognosis
- Secondary outcome
- Women
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gohar, Aisha
-
Gonçalves, Isabe ...
-
Vrijenhoek, Joyc ...
-
Haitjema, Saskia
-
van Koeverden, I ...
-
Nilsson, Jan
-
show more...
-
de Borst, Gert J ...
-
de Vries, Jean-P ...
-
Pasterkamp, Gera ...
-
den Ruijter, Hes ...
-
Björkbacka, Harr ...
-
de Jager, Saskia ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
International Jo ...
- By the university
-
Lund University