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Neuron-mediated gen...
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Liu, YaweiLund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
(författare)
Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE.
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
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2006-04-23
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Springer Science and Business Media LLC,2006
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:d63c814c-a6a2-4ba6-8b60-535b2fb6a60f
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https://lup.lub.lu.se/record/155789URI
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https://doi.org/10.1038/nm1402DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182695URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Neurons have been neglected as cells with a major immune-regulatory function because they do not express major histocompatibility complex class II. Our data show that neurons are highly immune regulatory, having a crucial role in governing T-cell response and central nervous system (CNS) inflammation. Neurons induce the proliferation of activated CD4+ T cells through B7-CD28 and transforming growth factor (TGF)-beta1–TGF-beta receptor signaling pathways, resulting in amplification of T-cell receptor signaling through phosphorylated ZAP-70, interleukin (IL)-2 and IL-9. The interaction between neurons and T cells results in the conversion of encephalitogenic T cells to CD25+TGF-beta1+CTLA-4+FoxP3+ T regulatory (Treg) cells that suppress encephalitogenic T cells and inhibit experimental autoimmune encephalomyelitis. Suppression is dependent on cytotoxic T lymphocyte antigen (CTLA)-4 but not TGF-beta1. Autocrine action of TGF-beta1, however, is important for the proliferative arrest of Treg cells. Blocking the B7 and TGF-beta pathways prevents the CNS-specific generation of Treg cells. These findings show that generation of neuron-dependent Treg cells in the CNS is instrumental in regulating CNS inflammation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Teige, IngridLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-ite
(författare)
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Birnir, BryndisLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Institute for Experimental Medical Science, University of Lund,Neuroinflammation Unit(Swepub:uu)brybi979
(författare)
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Issazadeh, ShohrehLund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)infl-sis
(författare)
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NeuroinflammationForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Medicine: Springer Science and Business Media LLC12:5, s. 518-5251546-170X1078-8956
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