(WFRF:(Lindgren Cecilia M.)) pers:(Luan Jian'an) pers:(Jarvelin Marjo Riitta)
Sökning: (WFRF:(Lindgren Cecilia M.)) pers:(Luan Jian'an) pers:(Jarvelin Marjo Riitta) > FTO genotype is ass...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 11527naa a2202485 4500 | |
| 001 | oai:lup.lub.lu.se:264098a2-9518-4ab8-af3e-b374f7e2cb2c | |
| 003 | SwePub | |
| 008 | 160401s2012 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-223054 | |
| 009 | oai:gup.ub.gu.se/170389 | |
| 009 | oai:prod.swepub.kib.ki.se:125614018 | |
| 024 | 7 | a https://lup.lub.lu.se/record/32443332 URI |
| 024 | 7 | a https://doi.org/10.1038/nature114012 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2230542 URI |
| 024 | 7 | a https://gup.ub.gu.se/publication/1703892 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1256140182 URI |
| 040 | a (SwePub)lud (SwePub)uud (SwePub)gud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Yang, Jian4 aut |
| 245 | 1 0 | a FTO genotype is associated with phenotypic variability of body mass index |
| 264 | c 2012-09-16 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2012 |
| 520 | a There is evidence across several species for genetic control of phenotypic variation of complex traits(1-4), such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using similar to 170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)(5-7), is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of similar to 0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation(9,10). Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Powell, Joseph E.4 aut |
| 700 | 1 | a Medland, Sarah E.4 aut |
| 700 | 1 | a Speliotes, Elizabeth K.4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
| 700 | 1 | a Maegi, Reedik4 aut |
| 700 | 1 | a Waite, Lindsay4 aut |
| 700 | 1 | a Smith, Albert Vernon4 aut |
| 700 | 1 | a Yerges-Armstrong, Laura M.4 aut |
| 700 | 1 | a Monda, Keri L.4 aut |
| 700 | 1 | a Hadley, David4 aut |
| 700 | 1 | a Mahajan, Anubha4 aut |
| 700 | 1 | a Li, Guo4 aut |
| 700 | 1 | a Kapur, Karen4 aut |
| 700 | 1 | a Vitart, Veronique4 aut |
| 700 | 1 | a Huffman, Jennifer E.4 aut |
| 700 | 1 | a Wang, Sophie R.4 aut |
| 700 | 1 | a Palmer, Cameron4 aut |
| 700 | 1 | a Esko, Toenu4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Demirkan, Ayse4 aut |
| 700 | 1 | a Isaacs, Aaron4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Heard-Costa, Nancy L.4 aut |
| 700 | 1 | a White, Charles4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Preuss, Michael4 aut |
| 700 | 1 | a Ziegler, Andreas4 aut |
| 700 | 1 | a Eriksson, Joelu Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xerjoe |
| 700 | 1 | a Kutalik, Zoltan4 aut |
| 700 | 1 | a Frau, Francesca4 aut |
| 700 | 1 | a Nolte, Ilja M.4 aut |
| 700 | 1 | a Van Vliet-Ostaptchouk, Jana V.4 aut |
| 700 | 1 | a Hottenga, Jouke-Jan4 aut |
| 700 | 1 | a Jacobs, Kevin B.4 aut |
| 700 | 1 | a Verweij, Niek4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Medina-Gomez, Carolina4 aut |
| 700 | 1 | a Estrada, Karol4 aut |
| 700 | 1 | a Bragg-Gresham, Jennifer Lynn4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Sidore, Carlo4 aut |
| 700 | 1 | a Tyrer, Jonathan4 aut |
| 700 | 1 | a Teumer, Alexander4 aut |
| 700 | 1 | a Prokopenko, Inga4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a Assimes, Themistocles L.4 aut |
| 700 | 1 | a Shuldiner, Alan R.4 aut |
| 700 | 1 | a Hui, Jennie4 aut |
| 700 | 1 | a Beilby, John P.4 aut |
| 700 | 1 | a McArdle, Wendy L.4 aut |
| 700 | 1 | a Hall, Peru Karolinska Institutet4 aut |
| 700 | 1 | a Haritunians, Talin4 aut |
| 700 | 1 | a Zgaga, Lina4 aut |
| 700 | 1 | a Kolcic, Ivana4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Zemunik, Tatijana4 aut |
| 700 | 1 | a Oostra, Ben A.4 aut |
| 700 | 1 | a Junttila, M. Juhani4 aut |
| 700 | 1 | a Groenberg, Henrik4 aut |
| 700 | 1 | a Schreiber, Stefan4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a Stephens, Jonathan4 aut |
| 700 | 1 | a Foad, Nicola S.4 aut |
| 700 | 1 | a Laitinen, Jaana4 aut |
| 700 | 1 | a Pouta, Anneli4 aut |
| 700 | 1 | a Kaakinen, Marika4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Vink, Jacqueline M.4 aut |
| 700 | 1 | a Wild, Sarah H.4 aut |
| 700 | 1 | a Navis, Gerjan4 aut |
| 700 | 1 | a Asselbergs, Folkert W.4 aut |
| 700 | 1 | a Homuth, Georg4 aut |
| 700 | 1 | a John, Ulrich4 aut |
| 700 | 1 | a Iribarren, Carlos4 aut |
| 700 | 1 | a Harris, Tamara4 aut |
| 700 | 1 | a Launer, Lenore4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Cadby, Gemma4 aut |
| 700 | 1 | a Palmer, Lyle J.4 aut |
| 700 | 1 | a James, Alan L.4 aut |
| 700 | 1 | a Musk, Arthur W.4 aut |
| 700 | 1 | a Ingelsson, Erik,d 1975-u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet4 aut0 (Swepub:uu)ering425 |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Beckmann, Jacques S.4 aut |
| 700 | 1 | a Waeber, Gerard4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Wright, Alan F.4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Khaw, Kay Tee4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Province, Michael A.4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Tardif, Jean-Claude4 aut |
| 700 | 1 | a Huikuri, Heikki V.4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Atwood, Larry D.4 aut |
| 700 | 1 | a Fox, Caroline S.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Erdmann, Jeanette4 aut |
| 700 | 1 | a Schunkert, Heribert4 aut |
| 700 | 1 | a Hengstenberg, Christian4 aut |
| 700 | 1 | a Stark, Klaus4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Cusi, Daniele4 aut |
| 700 | 1 | a Staessen, Jan A.4 aut |
| 700 | 1 | a Van der Klauw, Melanie M.4 aut |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Kathiresan, Sekar4 aut |
| 700 | 1 | a Jolley, Jennifer D.4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a de Geus, Eco J. C.4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Penninx, Brenda4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Chanock, Stephen J.4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Hamsten, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Witteman, Jacqueline C.4 aut |
| 700 | 1 | a Zillikens, M. Carola4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Zillikens, M. Carola4 aut |
| 700 | 1 | a Kiemeney, Lambertus A.4 aut |
| 700 | 1 | a Vermeulen, Sita H.4 aut |
| 700 | 1 | a Abecasis, Goncalo R.4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Schipf, Sabine4 aut |
| 700 | 1 | a Stumvoll, Michael4 aut |
| 700 | 1 | a Toenjes, Anke4 aut |
| 700 | 1 | a Spector, Tim D.4 aut |
| 700 | 1 | a North, Kari E.4 aut |
| 700 | 1 | a Lettre, Guillaume4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a Berndt, Sonja I.4 aut |
| 700 | 1 | a Heath, Andrew C.4 aut |
| 700 | 1 | a Madden, Pamela A. F.4 aut |
| 700 | 1 | a Nyholt, Dale R.4 aut |
| 700 | 1 | a Montgomery, Grant W.4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a McKnight, Barbara4 aut |
| 700 | 1 | a Strachan, David P.4 aut |
| 700 | 1 | a Hill, William G.4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Frayling, Timothy M.4 aut |
| 700 | 1 | a Hirschhorn, Joel N.4 aut |
| 700 | 1 | a Goddard, Michael E.4 aut |
| 700 | 1 | a Visscher, Peter M.4 aut |
| 710 | 2 | a Göteborgs universitetb Centre for Bone and Arthritis Research4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 490:7419, s. 267-272q 490:7419<267-272x 0028-0836x 1476-4687 |
| 856 | 4 | u http://dx.doi.org/10.1038/nature11401y FULLTEXT |
| 856 | 4 | u https://espace.library.uq.edu.au/view/UQ:285990/UQ285990_OA.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3244333 |
| 856 | 4 8 | u https://doi.org/10.1038/nature11401 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223054 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/170389 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125614018 |
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