NBQX, a competitive non-NMDA receptor antagonist, reduces degeneration due to focal spinal cord ischemia

von Euler, Mia, 1967- (författare): Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden

Seiger, A. (författare): Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden

Holmberg, L. (författare): Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden

Sundström, E. (författare): Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden

(creator_code:org_t)

New York, USA : Academic Press, 1994
1994
Engelska.
Ingår i: Experimental Neurology. - New York, USA : Academic Press. - 0014-4886 .- 1090-2430. ; 129:1, s. 163-168

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

We have used the laser-induced photochemical thrombosis model in adult rats to evaluate the significance of the non-N-methyl-D-aspartate (non-NMDA) subtype of glutamate receptors in situations of focal spinal cord ischemia. The animals were pretreated with the selective non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline (NBQX) or, for comparison, the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5-10-imine (MK-801). Neurological function was quantified using evaluations of motor score and inclined plane. The MK-801-treated rats had higher motor scores during the 3-week observation period while NBQX-treated rats only performed significantly better at 1 week. Both treatments caused significantly better performance in the inclined plane test. NBQX and MK-801 reduced the volume of necrosis by approximately 47% at 3 weeks postlesion. We conclude that blockade of both NMDA and non-NMDA subtypes of glutamate receptors reduces ischemic necrosis, possibly by preventing excessive stimulation of these receptors by released excitatory amino acids in the lesion area.

Av författaren/redakt...: von Euler, Mia, ...; Seiger, A.; Holmberg, L.; Sundström, E.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.