NBQX, a competitive non-NMDA receptor antagonist, reduces degeneration due to focal spinal cord ischemia

von Euler, Mia,1967-Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden (författare)

We have used the laser-induced photochemical thrombosis model in adult rats to evaluate the significance of the non-N-methyl-D-aspartate (non-NMDA) subtype of glutamate receptors in situations of focal spinal cord ischemia. The animals were pretreated with the selective non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline (NBQX) or, for comparison, the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5-10-imine (MK-801). Neurological function was quantified using evaluations of motor score and inclined plane. The MK-801-treated rats had higher motor scores during the 3-week observation period while NBQX-treated rats only performed significantly better at 1 week. Both treatments caused significantly better performance in the inclined plane test. NBQX and MK-801 reduced the volume of necrosis by approximately 47% at 3 weeks postlesion. We conclude that blockade of both NMDA and non-NMDA subtypes of glutamate receptors reduces ischemic necrosis, possibly by preventing excessive stimulation of these receptors by released excitatory amino acids in the lesion area.

Seiger, A.Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden (författare)
Holmberg, L.Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden (författare)
Sundström, E.Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden (författare)
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden (creator_code:org_t)

Ingår i:Experimental NeurologyNew York, USA : Academic Press129:1, s. 163-1680014-48861090-2430

Av författaren/redakt...: von Euler, Mia, ...; Seiger, A.; Holmberg, L.; Sundström, E.

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