Sökning: L773:1741 7015 OR L773:1741 7015 > Prostate-specific a...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04924naa a2200481 4500 | |
001 | oai:lup.lub.lu.se:1491eb4a-f34e-4424-a996-4112e9ce6035 | |
003 | SwePub | |
008 | 160401s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11851372 URI |
024 | 7 | a https://doi.org/10.1186/1741-7015-6-62 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ulmert, Davidu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Klinisk kemi, Malmö,Urological cancer, Malmö,Lund University Research Groups,Clinical Chemistry, Malmö4 aut0 (Swepub:lu)klke-dul |
245 | 1 0 | a Prostate-specific antigen at or before age 50 as a predictor of advanced prostate cancer diagnosed up to 25 years later: A case-control study |
264 | c 2008-02-15 | |
264 | 1 | b Springer Science and Business Media LLC,c 2008 |
520 | a Background: Based on a large, representative unscreened cohort from Malmo, Sweden, we have recently reported that a single prostate-specific antigen (PSA) measurement at or before age 50 is a strong predictor of prostate cancer occurring up to 25 years subsequently. We aimed to determine whether this association holds for advanced cancers, defined as clinical stage T3 or higher, or skeletal metastasis at the time of the cancer diagnosis. Methods: In 1974-1986 blood samples were obtained from a cohort of 21,277 men aged up to 50. Through 1999, 498 men were diagnosed with prostate cancer, and of these 161 had locally advanced or metastatic prostate cancers. Three controls, matched for age and date of venipuncture, were selected for each case. Conditional logistic regression was used to test associations between molecular markers and advanced cancer. Results: Median time from venipuncture to diagnosis was 17 years. Levels of all PSA forms and hK2 were associated with case status. Total PSA was a strong and statistically significant predictor of subsequent advanced cancer ( area under the curve 0.791; p < 0.0005). Two-thirds of the advanced cancer cases occurred in men with the top 20% of PSA levels (0.9 ng/ml or higher). Conclusion: A single PSA test taken at or before age 50 is a very strong predictor of advanced prostate cancer diagnosed up to 25 years later. This suggests the possibility of using an early PSA test to risk-stratify patients so that men at highest risk are the focus of the most intensive screening efforts. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Cronin, Angel M4 aut |
700 | 1 | a Björk, Thomasu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-tbj |
700 | 1 | a O'Brien, Matthew F4 aut |
700 | 1 | a Scardino, Peter T4 aut |
700 | 1 | a Eastham, James A4 aut |
700 | 1 | a Becker, Charlotteu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-cbe |
700 | 1 | a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe |
700 | 1 | a Vickers, Andrew J4 aut |
700 | 1 | a Lilja, Hansu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-hli |
710 | 2 | a Urologisk cancerforskning, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t BMC Medicined : Springer Science and Business Media LLCg 6q 6x 1741-7015 |
856 | 4 | u http://dx.doi.org/10.1186/1741-7015-6-6x freey FULLTEXT |
856 | 4 | u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/1741-7015-6-6 |
856 | 4 8 | u https://lup.lub.lu.se/record/1185137 |
856 | 4 8 | u https://doi.org/10.1186/1741-7015-6-6 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy