Lung cancer in ever- and never-smokers: findings from multi-population GWAS studies

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Fältnamn	Indikatorer	Metadata
000		14095naa a2201009 4500
001		oai:DiVA.org:umu-222350
003		SwePub
008		240318s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2223502 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-23-06132 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Li, Yafangu Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States4 aut
245	1 0	a Lung cancer in ever- and never-smokers :b findings from multi-population GWAS studies
264	1	b American Association For Cancer Research (AACR),c 2024
338		a electronic2 rdacarrier
520		a BACKGROUND: Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer.METHODS: We conducted a stratified multi-population (European, East Asian, and African descent) association study on 44,823 ever-smokers and 20,074 never-smokers to identify novel variants that were missed in the non-stratified analysis. Functional analysis including expression quantitative trait loci (eQTL) colocalization and DNA damage assays, and annotation studies were conducted to evaluate the functional roles of the variants. We further evaluated the impact of smoking quantity on lung cancer risk for the variants associated with ever-smoking lung cancer.RESULTS: Five novel independent loci, GABRA4, intergenic region 12q24.33, LRRC4C, LINC01088, and LCNL1 were identified with the association at two or three populations (P < 5 × 10-8). Further functional analysis provided multiple lines of evidence suggesting the variants affect lung cancer risk through excessive DNA damage (GABRA4) or cis-regulation of gene expression (LCNL1). The risk of variants from 12 independent regions, including the well-known CHRNA5, associated with ever-smoking lung cancer was evaluated for never-smokers, light-smokers (packyear ≤ 20), and moderate-to-heavy-smokers (packyear > 20). Different risk patterns were observed for the variants among the different groups by smoking behavior.CONCLUSIONS: We identified novel variants associated with lung cancer in only ever- or never-smoking groups that were missed by prior main-effect association studies. IMPACT: Our study highlights the genetic heterogeneity between ever- and never-smoking lung cancer and provides etiologic insights into the complicated genetic architecture of this deadly cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Xiao, Xiangjunu Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Li, Jianrongu Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Han, Younghunu Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Cheng, Chaou Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Fernandes, Gail F.u Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Slewitzke, Shannon E.u Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Rosenberg, Susan M.u Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Zhu, Mengu Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China4 aut
700	1	a Byun, Jinyoungu Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Bossé, Yohanu Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Canada4 aut
700	1	a McKay, James D.u Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut
700	1	a Albanes, Demetriosu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut
700	1	a Lam, Stephenu Department of Integrative Oncology, University of British Columbia, BC, Vancouver, Canada4 aut
700	1	a Tardon, Adoninau Public Health Department, University of Oviedo, Asturias, Spain4 aut
700	1	a Chen, Chuu Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700	1	a Bojesen, Stig E.u Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
700	1	a Landi, Maria T.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut
700	1	a Johansson, Mattiasu Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut
700	1	a Risch, Angelau Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria4 aut
700	1	a Bickeböller, Heikeu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 aut
700	1	a Wichmann, H-Erichu Helmholtz-Munich Institute of Epidemiology, Neuherberg, Germany4 aut
700	1	a Christiani, David C.u Departments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, MA, Boston, United States4 aut
700	1	a Rennert, Gadu Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel4 aut
700	1	a Arnold, Susanne M.u University of Kentucky, Markey Cancer Center, KY, Lexington, United States4 aut
700	1	a Goodman, Gary E.u Swedish Cancer Institute, WA, Seattle, United States4 aut
700	1	a Field, John K.u Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom4 aut
700	1	a Davies, Michael P Au Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom4 aut
700	1	a Shete, Sanjayu Department of Biostatistics, University of Texas, MD Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, University of Texas MD Anderson Cancer Center, TX, Houston, United States4 aut
700	1	a Marchand, Loïc Leu Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States4 aut
700	1	a Liu, Geoffreyu University Health Network- The Princess Margaret Cancer Centre, CA, Toronto, United States4 aut
700	1	a Hung, Rayjean J.u Luenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Canada4 aut
700	1	a Andrew, Angeline S.u Departments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, New Hampshire4 aut
700	1	a Kiemeney, Lambertus A.u Radboud University Medical Center, Nijmegen, Netherlands4 aut
700	1	a Sun, Ryanu Department of Biostatistics, University of Texas, MD Anderson Cancer Center, TX, Houston, United States4 aut
700	1	a Zienolddiny, Shanbehu National Institute of Occupational Health, Oslo, Norway4 aut
700	1	a Grankvist, Kjellu Umeå universitet,Institutionen för medicinsk biovetenskap4 aut0 (Swepub:umu)kjgr0002
700	1	a Johansson, Mikaelu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)mijo0025
700	1	a Caporaso, Neil E.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut
700	1	a Cox, Angelau Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom4 aut
700	1	a Hong, Yun-Chulu Department of Preventive Medicine, Seoul National University College of Medicine, Republic of South Korea, Seoul, South Korea4 aut
700	1	a Lazarus, Philipu Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States4 aut
700	1	a Schabath, Matthew B.u Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, Puerto Rico4 aut
700	1	a Aldrich, Melinda C.u Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States4 aut
700	1	a Schwartz, Ann G.u Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States4 aut
700	1	a Gorlov, Ivanu Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Purrington, Kristen S.u Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States4 aut
700	1	a Yang, Pingu Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, MN, Rochester, United States4 aut
700	1	a Liu, Yanhongu Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States4 aut
700	1	a Bailey-Wilson, Joan E.u National Human Genome Research Institute, NIH, MD, Baltimore, Liberia4 aut
700	1	a Pinney, Susan M.u University of Cincinnati College of Medicine, OH, Cincinnati, United States4 aut
700	1	a Mandal, Diptasriu Louisiana State University Health Sciences Center, LA, New Orleans, United States4 aut
700	1	a Willey, James C.u College of Medicine and Life Sciences, University of Toledo, Toledo, Ohio4 aut
700	1	a Gaba, Coletteu The University of Toledo College of Medicine, Toledo, Ohio4 aut
700	1	a Brennan, Paulu Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Canada4 aut
700	1	a Xia, Junu Creighton University School of Medicine, NE, Omaha, United States4 aut
700	1	a Shen, Hongbingu Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China4 aut
700	1	a Amos, Christopher I.u Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States4 aut
710	2	a Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United Statesb Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States4 org
773	0	t Cancer Epidemiology, Biomarkers and Preventiond : American Association For Cancer Research (AACR)g 33:3, s. 389-399q 33:3<389-399x 1055-9965x 1538-7755
856	4	u https://doi.org/10.1158/1055-9965.EPI-23-0613y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1845232/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222350
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-23-0613

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Av författaren/redakt...: Li, Yafang; Xiao, Xiangjun; Li, Jianrong; Han, Younghun; Cheng, Chao; Fernandes, Gail ...; visa fler...; Slewitzke, Shann ...; Rosenberg, Susan ...; Zhu, Meng; Byun, Jinyoung; Bossé, Yohan; McKay, James D.; Albanes, Demetri ...; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E.; Landi, Maria T.; Johansson, Matti ...; Risch, Angela; Bickeböller, Hei ...; Wichmann, H-Eric ...; Christiani, Davi ...; Rennert, Gad; Arnold, Susanne ...; Goodman, Gary E.; Field, John K.; Davies, Michael ...; Shete, Sanjay; Marchand, Loïc L ...; Liu, Geoffrey; Hung, Rayjean J.; Andrew, Angeline ...; Kiemeney, Lamber ...; Sun, Ryan; Zienolddiny, Sha ...; Grankvist, Kjell; Johansson, Mikae ...; Caporaso, Neil E ...; Cox, Angela; Hong, Yun-Chul; Lazarus, Philip; Schabath, Matthe ...; Aldrich, Melinda ...; Schwartz, Ann G.; Gorlov, Ivan; Purrington, Kris ...; Yang, Ping; Liu, Yanhong; Bailey-Wilson, J ...; Pinney, Susan M.; Mandal, Diptasri; Willey, James C.; Gaba, Colette; Brennan, Paul; Xia, Jun; Shen, Hongbing; Amos, Christophe ...; visa färre...

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