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FältnamnIndikatorerMetadata
00007091naa a2200553 4500
001oai:DiVA.org:uu-466650
003SwePub
008220131s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4666502 URI
0247 a https://doi.org/10.1038/s41598-021-04446-72 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Liu, Junu Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.4 aut
2451 0a A multi-omics study of circulating phospholipid markers of blood pressure
264 c 2022-01-12
264 1b NATURE PORTFOLIO,c 2022
338 a electronic2 rdacarrier
520 a High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct an in-depth multi-omics study of various phospholipids with systolic blood pressure (SBP) and diastolic blood pressure (DBP). The associations of blood pressure and 151 plasma phospholipids measured by electrospray ionization tandem mass spectrometry were performed by linear regression in five European cohorts (n = 2786 in discovery and n = 1185 in replication). We further explored the blood pressure-related phospholipids in Erasmus Rucphen Family (ERF) study by associating them with multiple cardiometabolic traits (linear regression) and predicting incident hypertension (Cox regression). Mendelian Randomization (MR) and phenome-wide association study (Phewas) were also explored to further investigate these association results. We identified six phosphatidylethanolamines (PE 38:3, PE 38:4, PE 38:6, PE 40:4, PE 40:5 and PE 40:6) and two phosphatidylcholines (PC 32:1 and PC 40:5) which together predicted incident hypertension with an area under the ROC curve (AUC) of 0.61. The identified eight phospholipids are strongly associated with triglycerides, obesity related traits (e.g. waist, waist-hip ratio, total fat percentage, body mass index, lipid-lowering medication, and leptin), diabetes related traits (e.g. glucose, insulin resistance and insulin) and prevalent type 2 diabetes. The genetic determinants of these phospholipids also associated with many lipoproteins, heart rate, pulse rate and blood cell counts. No significant association was identified by bi-directional MR approach. We identified eight blood pressure-related circulating phospholipids that have a predictive value for incident hypertension. Our cross-omics analyses show that phospholipid metabolites in the circulation may yield insight into blood pressure regulation and raise a number of testable hypothesis for future research.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a GENOME-WIDE ASSOCIATIONHIGH-THROUGHPUT; QUANTIFICATION; HYPERTENSION; HERITABILITY TRAIT; SPHOSPHATIDYL; CHOLINE; SPHINGOMYELIN; ADIPONECTIN; METABOLITES
7001 a de Vries, Paul S.u Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA.4 aut
7001 a Del Greco, Fabiola M.u Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Bolzano, Italy.4 aut
7001 a Johansson, Åsau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)asjoh108
7001 a Schraut, Katharina E.u Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.4 aut
7001 a Hayward, Carolineu Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland.4 aut
7001 a van Dijk, Ko Willemsu Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Internal Med, Div Endocrinol, Med Ctr, Leiden, Netherlands.4 aut
7001 a Franco, Oscar H.u Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland.4 aut
7001 a Hicks, Andrew A.u Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Bolzano, Italy.4 aut
7001 a Vitart, Veroniqueu Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland.4 aut
7001 a Rudan, Igoru Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.4 aut
7001 a Campbell, Harryu Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.4 aut
7001 a Polasek, Ozrenu Univ Split, Sch Med, Dept Publ Hlth, Split, Croatia.;Algebra Univ Coll, Ilica 242, Zagreb, Croatia.4 aut
7001 a Pramstaller, Peter P.u Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Bolzano, Italy.4 aut
7001 a Wilson, James F.u Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland.4 aut
7001 a Gyllensten, Ulfu Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Uppsala, Sweden.4 aut
7001 a van Duijn, Cornelia M.u Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.4 aut
7001 a Dehghan, Abbasu Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England.4 aut
7001 a Demirkan, Ayseu Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Surrey, Dept Clin & Expt Res, Sect Stat Multiomics, Surrey, England.;Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.4 aut
7102 a Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.b Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA.4 org
7730 t Scientific Reportsd : NATURE PORTFOLIOg 12:1q 12:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-021-04446-7y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1633567/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-021-04446-7.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466650
8564 8u https://doi.org/10.1038/s41598-021-04446-7

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