WFRF:(Mikuz M)
Sökning: WFRF:(Mikuz M) > (2005-2009) > Chromosomal imbalan...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03162naa a2200613 4500 | |
| 001 | oai:gup.ub.gu.se/294353 | |
| 003 | SwePub | |
| 008 | 240528s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2943532 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Verdorfer, I.4 aut |
| 245 | 1 0 | a Chromosomal imbalances, 11q21 rearrangement and MECT1-MAML2 fusion transcript in mucoepidermoid carcinomas of the salivary gland. |
| 264 | 1 | c 2009 |
| 520 | a The aim of this study was to determine genetic alterations in mucoepidermoid carcinomas of the salivary gland in association with clinical and histopathological parameters. Nineteen formalin-fixed, paraffin-embedded tumors were analysed by using comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH) on interphase nuclei and reverse transcriptase-polymerase chain reaction (RT-PCR) for detection of MECT1-MAML2 fusion transcript. The CGH analysis showed an overrepresentation of chromosome X and losses of entire chromosomes or regions on chromosome 1, 2, and 15 as the most frequent copy number changes. In 37% of the analysed tumors a MAML2-rearrangement by interphase FISH was detected, whereas 58% of the samples showed expression of MECT1-MAML2 fusion transcript. We conclude that the presence of MAML2-rearrangement as well as of MECT1-MAML2 fusion transcript may reflect a more favourable prognosis and may be a useful marker for clinical prediction of the biological behavior of these tumors as previously reported. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Aged | |
| 653 | a 80 and over | |
| 653 | a Carcinoma | |
| 653 | a Mucoepidermoid | |
| 653 | a genetics | |
| 653 | a Chromosome Aberrations | |
| 653 | a Chromosomes | |
| 653 | a Human | |
| 653 | a Pair 11 | |
| 653 | a Humans | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Oncogene Proteins | |
| 653 | a Fusion | |
| 653 | a genetics | |
| 653 | a RNA | |
| 653 | a Messenger | |
| 653 | a analysis | |
| 653 | a Salivary Gland Neoplasms | |
| 653 | a genetics | |
| 700 | 1 | a Fehr, Andreu Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xfehra |
| 700 | 1 | a Bullerdiek, J.4 aut |
| 700 | 1 | a Scholz, N.4 aut |
| 700 | 1 | a Brunner, A.4 aut |
| 700 | 1 | a Krugmann, J.4 aut |
| 700 | 1 | a Hager, M.4 aut |
| 700 | 1 | a Haufe, H.4 aut |
| 700 | 1 | a Mikuz, G.4 aut |
| 700 | 1 | a Scholtz, A.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
| 773 | 0 | t Oncology reportsg 22:2, s. 305-11q 22:2<305-11x 1021-335X |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/294353 |
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