The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour

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Nilsson, Kent WUppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Cent Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden. (författare)

The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour

Artikel/kapitelEngelska2008

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Elsevier BV,2008
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LIBRIS-ID:oai:DiVA.org:uu-16035
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16035URI
https://doi.org/10.1016/j.drugalcdep.2007.08.022DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111355URI
https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-52053URI

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Språk:engelska
Sammanfattning på:engelska

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Background: Antisocial behaviour has been associated with polymorphic variants in candidate genes and recently also gene-environmental interaction models have been presented. It has been suggested that antisocial behaviour, associated with alcohol consumption in males, is related to a variation in the monoamine oxidase A gene (MAO-A) promoter. Furthermore, platelet MAO-B activity has in several studies been reported to be low in male alcoholics, while this has not been the case with regard to female alcoholics. Aims of the present study were to: (1) investigate possible interactions between the MAO-A polymorphism, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among female adolescents; (2) to investigate if platelet MAO-B enzyme activity interacted with environment to predict female alcohol-related problems. Methods: A random sample of 114 female individuals from a total population of 16- and 19-year adolescents from a Swedish county, who volunteered to participate in the study, were interviewed, filled in a questionnaire and a blood sample was drawn. Results: In contrast to what has been reported in males, presence of the long (4-repeat) variant of the MAO-A gene in females interacted significantly with an unfavourable environment (poor family relations or maltreatment/abuse/sexual abuse) to increase the risk for high scores of alcohol-related problems. Furthermore, females with low platelet MAO-B activity showed an increased risk of alcohol-related problem behaviour in an unfavourable environment. Conclusions: Poor psychosocial environment interacts with the high activity MAO-A genotype and low platelet MAO-B enzyme activity to increase vulnerability for female adolescent alcohol-related problem behaviour.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
monoamine oxidase
platelet
alcohol drinking
sex difference
behaviour
risk-taking
adolescent
genes
environment
MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wargelius, Hanna-LinnUppsala universitet,Farmakologi,Uppsala Univ, Dept Neurosci, Pharmacol Unit, BMC, S-75124 Uppsala, Sweden.(Swepub:uu)hawar676 (författare)
Sjöberg, Rickard LUppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Cent Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden.(Swepub:umu)risj0004 (författare)
Leppert, JerzyUppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Cent Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden.(Swepub:uu)jelep103 (författare)
Oreland, LarsUppsala universitet,Farmakologi,Uppsala Univ, Dept Neurosci, Pharmacol Unit, BMC, S-75124 Uppsala, Sweden.(Swepub:uu)larsore (författare)
Uppsala universitetCentrum för klinisk forskning, Västerås (creator_code:org_t)

Sammanhörande titlar

Ingår i:Drug And Alcohol Dependence: Elsevier BV93:1-2, s. 51-620376-87161879-0046

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Av författaren/redakt...: Nilsson, Kent W; Wargelius, Hanna ...; Sjöberg, Rickard ...; Leppert, Jerzy; Oreland, Lars

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

Artiklar i publikationen: Drug And Alcohol ...

Av lärosätet: Uppsala universitet; Umeå universitet; Mälardalens universitet

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