Is there an increased risk for drug treated attention deficit/hyperactivity disorder in children born after in vitro fertilization?

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Fältnamn	Indikatorer	Metadata
000		04308naa a2200469 4500
001		oai:DiVA.org:liu-68822
003		SwePub
008		110608s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:38653614-9dc1-48f6-8517-375ca08711fd
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-688222 URI
024	7	a https://doi.org/10.1016/j.ejpn.2010.12.0042 DOI
024	7	a https://lup.lub.lu.se/record/18323462 URI
040		a (SwePub)liud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Källén, Bengtu Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Tornblad Institute, University of Lund4 aut0 (Swepub:lu)anat-bka
245	1 0	a Is there an increased risk for drug treated attention deficit/hyperactivity disorder in children born after in vitro fertilization?
264	1	b Elsevier Science B.V., Amsterdam,c 2011
338		a print2 rdacarrier
520		a Background: There is mounting evidence that children born after in vitro fertilization (IVF) run an increased risk of neurological complications and notably cerebral palsy. Whether developmental disturbances occur more often than expected is debated. Aim: To investigate the risk for ADHD in children conceived after IVF. Methods: Children conceived after IVF and born between 1982 and 2005 were identified from all IVF clinics in Sweden. Children who developed attention deficit/hyperactivity disorder (ADHD) were identified with the use of a register over all prescribed drugs in Sweden, using prescriptions for methylphenidate or atomixetine as indicators of ADHD. Maternal and neonatal characteristics were obtained by linkage with the Medical Birth Register and relevant confounders were adjusted for using Mantel-Haenszel procedures. We studied 28158 children born after IVF and compared them with 2417886 children in the population. Results: After adjustment for year of birth, maternal age, parity, smoking, BMI, and maternal education and after exclusion of women who did not cohabit, a weak but statistically significant association was found with an odds ratio = 1.18, 95% confidence interval 1.03-1.36. The effect was stronger in girls (OR = 1.40) than boys (OR = 1.11) but this difference could be random. After adjustment for length of involuntary childlessness, the OR decreased slightly and lost statistical significance. Conclusions: The study suggests a weak association between IVF and drug treated ADHD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653		a Attention deficit/hyperactivity disorder
653		a Confounding
653		a Epidemiology
653		a In vitro fertilization
653		a MEDICINE
653		a MEDICIN
700	1	a Finnström, Orvaru Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)orvfi31
700	1	a Lindam, Anna Pu Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Stockholm4 aut
700	1	a Nilsson, Emma M Eu Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Stockholm4 aut
700	1	a Nygren, Karl-Göstau IVF and Fertility Clinic, Sophiahemmet, Stockholm4 aut
700	1	a Otterblad Olausson, Petra Mu Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Stockholm4 aut
710	2	a Tornbladinstitutetb Forskargrupper vid Lunds universitet4 org
773	0	t EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGYd : Elsevier Science B.V., Amsterdamg 15:3, s. 247-253q 15:3<247-253x 1090-3798
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/21288748?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1016/j.ejpn.2010.12.004y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68822
856	4 8	u https://doi.org/10.1016/j.ejpn.2010.12.004
856	4 8	u https://lup.lub.lu.se/record/1832346

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Av författaren/redakt...: Källén, Bengt; Finnström, Orvar; Lindam, Anna P; Nilsson, Emma M ...; Nygren, Karl-Gös ...; Otterblad Olauss ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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Av lärosätet: Linköpings universitet; Lunds universitet

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